中华急危重症护理杂志 ›› 2026, Vol. 7 ›› Issue (10): 1201-1208.doi: 10.3761/j.issn.2096-7446.2026.10.007
王钰炜1(
), 王飒2,*(
), 许书荣1, 闫丹萍1, 周帅帅1, 刘亚洁1, 王美玲1
收稿日期:2025-10-26
出版日期:2026-10-10
发布日期:2026-10-14
通讯作者:
*王飒,E-mail:2506025@zju.edu.cn
作者简介:王钰炜:女,硕士,主任护师,E-mail:zrwyw@zju.edu.cn王钰炜:研究问题酝酿与构思、方法学指导、起草论文、论文修改、经费支持;王飒:对论文的知识性内容作批判性审阅、方法学指导、论文修改;许书荣:起草论文、论文修改;闫丹萍:采集数据;周帅帅:论文修改;刘亚洁:对论文的知识性内容作批判性审阅;王美玲:文献检索与筛选
基金资助:
WANG Yuwei1(
), WANG Sa2,*(
), XU Shurong1, YAN Danping1, ZHOU Shuaishuai1, LIU Yajie1, WANG Meiling1
Received:2025-10-26
Online:2026-10-10
Published:2026-10-14
Contact:
*WANG Sa,E-mail:2506025@zju.edu.cn
Supported by:摘要:
目的 梳理并总结院外心搏骤停(out-of-hospital cardiac arrest,OHCA)患者在急诊救治中的体温管理策略。 方法 根据范围综述的研究规范,系统检索PubMed、Web of Science、中国知网、万方数据库等8个数据库,检索时限为建库至2025年6月24日。筛选纳入文献后,对OHCA患者在急诊救治中的目标体温范围、体温调节方式、体温监测方式、药物使用情况等进行归纳。 结果 共纳入25篇文献,体温管理措施均为降温,具体方式为冷液体输注与体表降温,常见的体温监测方式为膀胱温、食管温与鼓膜温,常见的药物使用为镇静镇痛药与肌松药,但使用时机与剂量在各研究中差异较大。 结论 OHCA患者在急诊救治中的体温调节探索受限于区域、制度、硬件水平等因素,尚不深入,不同区域间存在较大差异,且近5年国内外报道较少,存在研究空白。未来应在考虑不同医疗机构设备条件的基础上,对体温调节措施与监测方式进行进一步探索。
王钰炜, 王飒, 许书荣, 闫丹萍, 周帅帅, 刘亚洁, 王美玲. 院外心搏骤停患者急诊救治中体温管理策略的范围综述[J]. 中华急危重症护理杂志, 2026, 7(10): 1201-1208.
WANG Yuwei, WANG Sa, XU Shurong, YAN Danping, ZHOU Shuaishuai, LIU Yajie, WANG Meiling. Temperature management strategies for out-of-hospital cardiac arrest patients in the emergency setting:a scoping review[J]. Chinese Journal of Emergency and Critical Care Nursing, 2026, 7(10): 1201-1208.
| [1] |
Gräsner JT, Herlitz J, Tjelmeland IBM, et al. European resuscitation council guidelines 2021:epidemiology of cardiac arrest in Europe[J]. Resuscitation, 2021, 161:61-79.
doi: 10.1016/j.resuscitation.2021.02.007 |
| [2] |
Dwivedi DB, Ball J, Smith K, et al. Incidence and outcomes of out-of-hospital cardiac arrest from initial asystole:a systematic review and meta-analysis[J]. Resuscitation, 2025, 212:110629.
doi: 10.1016/j.resuscitation.2025.110629 |
| [3] |
Okada Y, Shahidah N, Ng YY, et al. Outcome assessment for out-of-hospital cardiac arrest patients in Singapore and Japan with initial shockable rhythm[J]. Crit Care, 2023, 27(1):351.
doi: 10.1186/s13054-023-04636-x |
| [4] | 白雪, 陈梦飞, 唐玉娇, 等. 心搏骤停流行病学调查及其危险因素研究现状[J]. 中华危重病急救医学, 2024, 36(4):445-448. |
| Bai X, Chen MF, Tang YJ, et al. Epidemiologic investigation of cardiac arrest and current research status on its risk factors analysis[J]. Chin Crit Care Med, 2024, 36(4):445-448. | |
| [5] | Barker M, Sekhon M, Krychtiuk KA, et al. Targeted temperature management after out-of-hospital cardiac arrest:integrating evidence into real world practice[J]. Can J Cardiol, 2023, 39(4):385-393. |
| [6] |
Chiu PY, Chung CC, Tu YK, et al. Therapeutic hypothermia in patients after cardiac arrest:a systematic review and meta-analysis of randomized controlled trials[J]. Am J Emerg Med, 2023, 71:182-189.
doi: 10.1016/j.ajem.2023.06.040 |
| [7] |
Wongtanasarasin W, Nishijima DK, Isaranuwatchai W, et al. Real-world cost-effectiveness of targeted temperature management in out-of-hospital cardiac arrest survivors:results from an aca-demic medical center[J]. World J Emerg Med, 2025, 16(1):28-34.
doi: 10.5847/wjem.j.1920-8642.2025.012 pmid: 39906108 |
| [8] |
Nielsen N, Wetterslev J, Cronberg T, et al. Targeted temperature management at 33 ℃ versus 36 ℃ after cardiac arrest[J]. N Engl J Med, 2013, 369(23):2197-2206.
doi: 10.1056/NEJMoa1310519 |
| [9] |
Dankiewicz J, Cronberg T, Lilja G, et al. Hypothermia versus normothermia after out-of-hospital cardiac arrest[J]. N Engl J Med, 2021, 384(24):2283-2294.
doi: 10.1056/NEJMoa2100591 |
| [10] |
Tirkkonen J, Skrifvars MB. Change of target temperature from 36 ℃ to strict fever avoidance only in comatose cardiac arrest survivors-A before and after study[J]. Resuscitation, 2023, 188:109796.
doi: 10.1016/j.resuscitation.2023.109796 |
| [11] |
Nolan JP, Neumar RW, Adrie C, et al. Post-cardiac arrest syndrome:epidemiology,pathophysiology,treatment,and prognostication. A Scientific Statement from the International Liaison Committee on Resuscitation;the American Heart Association Emergency Cardiovascular Care Committee;the Council on Cardiovascular Surgery and Anesthesia;the Council on Cardiopulmonary,Perioperative,and Critical Care;the Council on Clinical Cardiology;the Council on Stroke[J]. Resuscitation, 2008, 79(3):350-379.
doi: 10.1016/j.resuscitation.2008.09.017 |
| [12] |
Sekhon MS, Ainslie PN, Griesdale DE. Clinical pathophysiology of hypoxic ischemic brain injury after cardiac arrest:a “two-hit” model[J]. Crit Care, 2017, 21(1):90.
doi: 10.1186/s13054-017-1670-9 |
| [13] | Greif R, Bray JE, Djärv T, et al. 2024 International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations:summary from the basic life dupport;sdvanced life support;pediatric life support;neonatal life support;education,implementation,and teams;and first aid task forces[J]. Circulation,2024, 150(24):e580-e687. |
| [14] |
金丁萍, 王飒, 王钰炜, 等. 创伤患者低体温影响因素及管理策略的范围综述[J]. 中华急危重症护理杂志, 2025, 6(9):1082-1088.
doi: 10.3761/j.issn.2096-7446.2025.09.009 |
| Jin DP, Wang S, Wang YW, et al. Factors influencing hypothermia in trauma patients and management strategies:a scoping review[J]. Chin J Emerg Crit Care Nurs, 2025, 6(9):1082-1088. | |
| [15] | Aromataris E, Lockwood C, Porritt K, et al. JBI Manual for Evidence Synthesis[EB/OL]. (2024)[2025-08-20]. https://synthesismanual.jbi.global. |
| [16] |
Takeda Y, Kawashima T, Kiyota K, et al. Feasibility study of immediate pharyngeal cooling initiation in cardiac arrest patients after arrival at the emergency room[J]. Resuscitation, 2014, 85(12):1647-1653.
doi: 10.1016/j.resuscitation.2014.09.014 pmid: 25263513 |
| [17] |
Debaty G, Maignan M, Savary D, et al. Impact of intra-arrest therapeutic hypothermia in outcomes of prehospital cardiac arrest:a randomized controlled trial[J]. Intensive Care Med, 2014, 40(12):1832-1842.
doi: 10.1007/s00134-014-3519-x |
| [18] |
Macchini E, Dillenbeck E, Jonsson M, et al. Intra-arrest therapeutic hypothermia and neurologic outcome in patients admitted after out-of-hospital cardiac arrest:a post hoc analysis of the princess trial[J]. Brain Sci, 2022, 12(10):1374.
doi: 10.3390/brainsci12101374 |
| [19] |
Yochum C, Utley R. Initiation of therapeutic hypothermia in the emergency department:a quality improvement project[J]. Adv Emerg Nurs J, 2017, 39(1):52-58.
doi: 10.1097/TME.0000000000000131 pmid: 28141610 |
| [20] |
Schenfeld EM, Studnek J, Heffner AC, et al. Effect of prehospital initiation of therapeutic hypothermia in adults with cardiac arrest on time-to-target temperature[J]. CJEM, 2015, 17(3):240-247.
doi: 10.2310/8000.2014.141307 |
| [21] |
Kämäräinen A, Virkkunen I, Tenhunen J, et al. Induction of therapeutic hypothermia during prehospital CPR using ice-cold intravenous fluid[J]. Resuscitation, 2008, 79(2):205-211.
doi: 10.1016/j.resuscitation.2008.07.003 pmid: 18809236 |
| [22] |
Bernard S, Buist M, Monteiro O, et al. Induced hypothermia using large volume,ice-cold intravenous fluid in comatose survivors of out-of-hospital cardiac arrest:a preliminary report[J]. Resuscitation, 2003, 56(1):9-13.
doi: 10.1016/S0300-9572(02)00276-9 |
| [23] |
Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia[J]. N Engl J Med, 2002, 346(8):557-563.
doi: 10.1056/NEJMoa003289 |
| [24] |
Bernard SA, Jones BM, Horne MK. Clinical trial of induced hypothermia in comatose survivors of out-of-hospital cardiac arrest[J]. Ann Emerg Med, 1997, 30(2):146-153.
doi: 10.1016/s0196-0644(97)70133-1 pmid: 9250636 |
| [25] |
Bernard SA, Smith K, Cameron P, et al. Induction of therapeutic hypothermia by paramedics after resuscitation from out-of-hospital ventricular fibrillation cardiac arrest:a randomized controlled trial[J]. Circulation, 2010, 122(7):737-742.
doi: 10.1161/CIRCULATIONAHA.109.906859 |
| [26] |
Bernard SA, Smith K, Cameron P, et al. Induction of prehospital therapeutic hypothermia after resuscitation from nonventricular fibrillation cardiac arrest[J]. Crit Care Med, 2012, 40(3):747-753.
doi: 10.1097/CCM.0b013e3182377038 |
| [27] |
Look X, Li HH, Ng M, et al. Randomized controlled trial of internal and external targeted temperature management methods in post-cardiac arrest patients[J]. Am J Emerg Med, 2018, 36(1):66-72.
doi: 10.1016/j.ajem.2017.07.017 |
| [28] | Oceja IB, Martin FJG, Melendez AGDV, et al. Results of using a therapeutic hypothermia protocol after cardiac arrest:Design and application by an emergency medical service and a hospital emergency department[J]. Emergencias, 2012, 24(1):39-43. |
| [29] |
Scales DC, Cheskes S, Verbeek PR, et al. Prehospital cooling to improve successful targeted temperature management after cardiac arrest:a randomized controlled trial[J]. Resuscitation, 2017, 121:187-194.
doi: S0300-9572(17)30650-0 pmid: 28988962 |
| [30] |
Srivilaithon W, Muengtaweepongsa S. The outcomes of targeted temperature management after cardiac arrest at emergency department:a real-world experience in a developing country[J]. Ther Hypothermia Temp Manag, 2017, 7(1):24-29.
doi: 10.1089/ther.2016.0014 pmid: 27835072 |
| [31] |
Takeuchi I, Takehana H, Satoh D, et al. Effect of hypothermia therapy after outpatient cardiac arrest due to ventricular fibrillation[J]. Circ J, 2009, 73(10):1877-1880.
pmid: 19661722 |
| [32] |
Uray T, Haugk M, Sterz F, et al. Surface cooling for rapid induction of mild hypothermia after cardiac arrest:design determines efficacy[J]. Acad Emerg Med, 2010, 17(4):360-367.
doi: 10.1111/acem.2010.17.issue-4 |
| [33] |
Uray T, Mayr FB, Stratil P, et al. Prehospital surface cooling is safe and can reduce time to target temperature after cardiac arrest[J]. Resuscitation, 2015, 87:51-56.
doi: 10.1016/j.resuscitation.2014.10.026 pmid: 25447355 |
| [34] |
Youn CS, Park KN, Kim SH, et al. The cumulative partial pressure of arterial oxygen is associated with neurological outcomes after cardiac arrest treated with targeted temperature management[J]. Crit Care Med, 2018, 46(4):e279-e285.
doi: 10.1097/CCM.0000000000002935 |
| [35] |
Kämäräinen A, Virkkunen I, Tenhunen J, et al. Prehospital thera-peutic hypothermia for comatose survivors of cardiac arrest:a randomized controlled trial[J]. Acta Anaesthesiol Scand, 2009, 53(7):900-907.
doi: 10.1111/j.1399-6576.2009.02015.x pmid: 19496762 |
| [36] |
Kim F, Nichol G, Maynard C, et al. Effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest:a randomized clinical trial[J]. JAMA, 2014, 311(1):45-52.
doi: 10.1001/jama.2013.282173 |
| [37] |
Kim F, Olsufka M, Longstreth WT Jr, et al. Pilot randomized clinical trial of prehospital induction of mild hypothermia in out-of-hospital cardiac arrest patients with a rapid infusion of 4 degrees C normal saline[J]. Circulation, 2007, 115(24):3064-3070.
pmid: 17548731 |
| [38] |
Kliegel A, Janata A, Wandaller C, et al. Cold infusions alone are effective for induction of therapeutic hypothermia but do not keep patients cool after cardiac arrest[J]. Resuscitation, 2007, 73(1):46-53.
pmid: 17241729 |
| [39] |
Kliegel A, Losert H, Sterz F, et al. Cold simple intravenous infusions preceding special endovascular cooling for faster induction of mild hypothermia after cardiac arrest:a feasibility study[J]. Resuscitation, 2005, 64(3):347-351.
doi: 10.1016/j.resuscitation.2004.09.002 |
| [40] | Skulec R, Truhlár A, Seblová J, et al. Pre-hospital cooling of patients following cardiac arrest is effective using even low volumes of cold saline[J]. Crit Care, 2010, 14(6):R231. |
| [41] |
Yenari MA, Han HS. Neuroprotective mechanisms of hypothermia in brain ischaemia[J]. Nat Rev Neurosci, 2012, 13(4):267-278.
doi: 10.1038/nrn3174 pmid: 22353781 |
| [42] | Perman SM, Elmer J, Maciel CB, et al. 2023 American Heart Association focused update on adult advanced cardiovascular life support:an update to the American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care[J]. Circulation,2024, 149(5):e254-e273. |
| [43] |
Nolan JP, Sandroni C, Andersen LW, et al. ERC-ESICM guidelines on temperature control after cardiac arrest in adults[J]. Resuscitation, 2022, 172:229-236.
doi: 10.1016/j.resuscitation.2022.01.009 pmid: 35131119 |
| [44] |
Kawahara N, Takayama W, Morishita K, et al. Effects of prehospital advanced airway management on cardiac arrest patients who underwent extracorporeal cardiopulmonary resuscitation[J]. Sci Rep, 2025, 15(1):10670.
doi: 10.1038/s41598-025-95176-7 |
| [45] |
Shin J, Kim J, Song K, et al. Core temperature measurement in therapeutic hypothermia according to different phases:Comparison of bladder,rectal,and tympanic versus pulmonary artery methods[J]. Resuscitation, 2013, 84(6):810-817.
doi: 10.1016/j.resuscitation.2012.12.023 |
| [46] |
Sweeting P, Murphy M, Geraghty S, et al. Peripheral thermometry:Agreement between non-touch infrared versus traditional modes in an adult population[J]. J Adv Nurs, 2022, 78(2):425-433.
doi: 10.1111/jan.v78.2 |
| [47] | Perkins GD, Neumar R, Hsu CH, et al. Improving outcomes after post-cardiac arrest brain injury:a scientific statement from the international liaison committee on resuscitation[J]. Circulation, 2024, 150(7):e158-e180. |
| [48] |
Callaway CW. Targeted temperature management with hypothermia for comatose patients after cardiac arrest[J]. Clin Exp Emerg Med, 2023, 10(1):5-17.
doi: 10.15441/ceem.23.012 pmid: 36796779 |
| [49] |
Nolan JP, Sandroni C, Böttiger BW, et al. European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021:post-resuscitation care[J]. Intensive Care Med, 2021, 47(4):369-421.
doi: 10.1007/s00134-021-06368-4 |
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