危重患者急性胃肠损伤影响因素的Meta分析

doi:10.3761/j.issn.2096-7446.2025.11.016

Abstract

Abstract:

Objective To systematically review the influencing factors for acute gastrointestinal injury（AGI） occurrence in critically ill patients. Methods PubMed，Web of Science，Cochrane Library，CNKI，Wanfang Data，VIP，and CBM were searched for studies related to influencing factors of AGI occurrence in critically ill patients from inception to March 12，2 024.Two researchers independently screened literature，extracted data，and assessed the quality of included studies. Meta-analysis was performed using R software（version 4.3.3）. Results A total of 17 literatures were included，with a total of 187 686 subjects，involving 47 influencing factors. Meta-analysis showed that fast plasma glucose （OR = 154.28， 95%CI = 21.79-1 092.42， P < 0.01），procalcitonin （OR = 26.82， 95%CI = 1.26-568.82， P = 0.03），D-lactate （OR = 3.33，95%CI = 1.87-5.96，P < 0.01），lactic acid （OR = 1.41， 95%CI=1.15-1.73， P < 0.01），insulin resistance index （OR = 81.74， 95%CI = 12.26-545.14， P < 0.01），intra-abdominal pressure （OR=3.03，95%CI = 1.31-7.03，P < 0.01）， multiple organ dysfunction syndrome （OR = 5.26，95%CI = 1.65-16.69，P < 0.01）， heart failure （OR = 2.93，95%CI = 1.53-5.60，P < 0.01）， hypotension （OR = 5.24，95%CI = 1.94-14.13，P < 0.01）， mechanical ventilation （OR = 3.52，95%CI = 2.19-5.67，P < 0.01），length of ICU stay （OR = 1.64，95%CI = 1.14-2.35，P < 0.01），acute physiology and chronic health evalua-tion scoring system Ⅱ score （OR = 1.11，95%CI= 1.00 - 1.23，P < 0.05） and sequential organ failure assessment score （OR=1.12，95%CI=1.03-1.21，P<0.01） were risk factors for AGI in critically ill patients. And antral motility index （OR=0.33，95%CI=0.17-0.62，P<0.01） was a protective factor. Conclusion There are many factors affecting the occurrence of AGI in critically ill patients. Healthcare professionals should identify relevant factors as early as possible，and implement targeted prevention and treatment measures to reduce the incidence of AGI and related complications，so as to improve the clinical prognosis of critically ill patients.

Key words: Critically Ill Patients, Acute Gastrointestinal Injury, Influencing Factors, Meta-Analysis, Eviden-ce-Based Nursing

FANG Bo, SHEN Zhijie, WANG Yan. Influencing factors of acute gastrointestinal injury in critically ill patients：a meta-analysis[J]. Chinese Journal of Emergency and Critical Care Nursing, 2025, 6(11): 1377-1385.

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References 30

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Influencing factors of acute gastrointestinal injury in critically ill patients：a meta-analysis

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