Objective To construct a delirium grading management plan for critically ill patients guided by combined delirium prediction models，and to preliminarily explore its application effects. Methods Through literature review and Delphi expert consultation，a delirium grading management plan for critically ill patients guided by combined delirium prediction models was constructed. Using convenience sampling method，169 patients admitted from December 2023 to February 2024 were recruited as the experimental group，which was intervened according to the constructed management plan，and 147 patients admitted from September to November 2023 were included as the control group and received routine care. The incidence of delirium was compared between the two groups. Results A total of 16 experts completed two rounds of consultation. The response rates of effective questionnaires were 100% and 93.75%，respectively，and the expert authority coefficients were both 0.89. After 2 rounds of expert consultation，the Kendall coefficients of the importance and operability of the items were 0.151 and 0.193，respectively（P<0.01）. The final plan included 10 primary items，31 secondary items，and 34 tertiary items. The application results showed that the incidence of delirium in the experimental group（12.42%） was lower than that in the control group（21.09%），and the difference was statistically significant（P=0.038）. Conclusion The delirium grading management plan for critically ill patients，guided by the combined delirium prediction models，provides theoretical basis and practical guidance for multidisciplinary cooperation in standardized management of delirium in ICU，and can reduce the incidence of delirium in critically ill patients.
