Objective To explore the application effect of time-axis oriented temperature protection strategy in patients undergoing multiple trauma surgery. Methods 94 patients with multiple injuries treated in a Grade-A tertiary hospital in Xi ’an City from January 2024 to December 2024 were selected as the research subjects. Among them,47 patients treated from January to June 2024 were assigned to the control group,and 47 patients treated from July to December 2024 were assigned to the experimental group. The control group received routine temperature management in the operating room,while the experimental group received a time-axis oriented temperature protection strategy. The core body temperatures of the two groups at the time of entering the operating room(T0),30 minutes into the surgery(T1),90 minutes into the surgery(T2),and at the time of incision closure(T3) were compared,as well as the incidence of intraoperative shivering and the incidence of adverse events.Results At T2 and T3,the core body temperatures of the experimental group were higher than those of the control group[(35.95±0.42) ℃ vs(35.73±0.59) ℃,(36.17±0.30) ℃ vs(35.89±0.56) ℃],all P<0.05. The incidence of intraoperative shivering of the experimental group was lower than that of the control group(2.13% vs 17.02%,P< 0.05). There was no statistically significant difference in the incidence of adverse events between the two groups (P>0.05).Conclusion Compared with routine temperature management in the operating room,the time-axis-based temperature protection strategy has a more significant effect on maintaining body temperature in patients with multiple injuries undergoing surgery,and reduces the rate of intraoperative shivering.