eISSN 2097-6046
ISSN 2096-7446
CN 10-1655/R
Responsible Institution:China Association for Science and Technology
Sponsor:Chinese Nursing Association

Chinese Journal of Emergency and Critical Care Nursing ›› 2025, Vol. 6 ›› Issue (10): 1220-1222.doi: 10.3761/j.issn.2096-7446.2025.10.012

• Critical Care Research • Previous Articles     Next Articles

Nursing care for a patient with plasma cell disease undergoing chimeric antigen receptor T-cell immunotherapy complicated with cytokine release syndrome

LI Ying(), ZHU Yan, ZENG Fei   

  • Received:2024-11-25 Online:2025-10-10 Published:2025-09-25

Abstract:

This article summarized the nursing experience of a patient with plasma cell disease who developed cytokine release syndrome(CRS) following chimeric antigen receptor T-cell(CAR-T) therapy. The patient exhibited severe clinical manifestations of CRS,including altered mental status,chills with high fever,hypotension,and pancytopenia. A comprehensive nursing approach was implemented,which included rigorous monitoring of the patient’s condition,prompt initiation of emergency response protocols,circulatory support,continuous renal replacement therapy(CRRT),and infection prevention. As a result of these measures,the patient was successfully treated and discharged. Follow-up revealed that the patient had a good quality of life.

Key words: Chimeric Antigen Receptor T-cell Therapy, Cytokine Release Syndrome, Critical Care Nursing