颅脑损伤患者轻度认知功能障碍影响因素的Meta分析

doi:10.3761/j.issn.2096-7446.2023.03.015

摘要/Abstract

摘要： 目的通过Meta分析明确颅脑损伤患者轻度认知障碍的影响因素。方法检索中国知网、万方数据库、中国生物医学文献数据库、PubMed、Embase、Cochrane Library等数据库,从建库至2022年8月的所有有关颅脑损伤患者轻度认知功能障碍的文献及纳入文献的参考文献,由2名评价人员按照标准独立筛选文献、提取资料、评价文献质量。采用RevMan 5.3软件对资料进行Meta分析。结果共纳入17篇文献,16个危险因素,样本量为11 750例。Meta分析结果显示,年龄（OR=3.03）、受教育程度（OR=2.46）、额叶受损（OR=4.84）、颞叶受损（OR=6.01）、左半球受损（OR=5.02）、多部位损伤（OR=6.80）是颅脑损伤患者轻度认知障碍的影响因素。结论临床护理人员应加强对颅脑损伤患者认知障碍的评估和筛查,重视认知储备（年龄及受教育程度）的潜在影响及不同部位受损的认知域特征,及早进行有针对性的干预,以改善患者临床结局。

关键词: 颅脑损伤, 认知障碍, 影响因素分析, 危重病护理, 专题Meta分析

Abstract: Objective To identify the risk factors of mild cognitive impairment in patients with traumatic brain injury by meta-analysis. Methods China National Knowledge Network,Wanfang Database,China Biomedical Literature Database,PubMed,Embase,Cochrane Library and other databases were searched for studies on mild cognitive impairment in patients with craniocerebral injury from the establishment of the database to August 2022 and the references of included studies were included. Two reviewers screened the literature according to the inclusion and exclusion criteria,and extracted data,assessed the quality of included studies independently. Meta-analysis was conducted by Rev Man 5.3. Results A total of 17 studies and 16 risk factors were included,with a sample size of 11 750 cases. The meta-analysis result showed that the risk factors were age（OR=3.03）,education level（OR=2.46）,damage of frontal lobe（OR=4.84）,damage of temporal lobe（OR=6.01）,damage of left hemisphere（OR=5.02）,multi-site injury（OR=6.80）. Conclusion Clinical nursing staff should strengthen the assessment and screening of cognitive impairment in patients with brain injury,pay attention to the potential impact of cognitive reserve（age and education level）and the characteristics of different damaged areas of cognitive domain,target early and effective intervention to improve the clinical outcome of patients.

Key words: Craniocerebral Trauma, Cognition Disorders, Factor Analysis, Statistical, Critical Care Nursing, Meta-Analysis as Topic

张雅芝, 厉春林, 刘园园, 黄钊. 颅脑损伤患者轻度认知功能障碍影响因素的Meta分析[J]. 中华急危重症护理杂志, 2023, 4(3): 263-269.

ZHANG Yazhi, LI Chunlin, LIU Yuanyuan, HUANG Zhao. Meta-analysis of influencing factors of mild cognitive impairment in patients with traumatic brain injury[J]. Chinese Journal of Emergency and Critical Care Nursing, 2023, 4(3): 263-269.

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