Objective  To compare the effectiveness and acceptance of self-led training and instructor-led trainingon cardiopulmonary resuscitation  (CPR)  training among nursing undergraduate students. Methods   We recruited 95 nursing undergraduate students who practiced nursing in Emergency Department of the Second Affiliated Hospital of Chongqing Medical University from November 2018 to April 2019. They were divided into the experimental group (the self-led training,n=48) and the control group(instructor-led training,n=47)by the sealed envelope method. Skill tests were performed on the  day of training  and  the  seventh  day  after  training,Students'  attitude  were  assessed by  the  questionnaire  after  the  training.  Results   There was no  statistical difference in CPR skill  scores between two groups immediately after training(P>0.05),and was statistical difference on the 7th day(P<0.001).The will-ingness to accept the is a different training significant difference self-led model"betweew trammg whichthe twnmodel was 100%,whileindicated that they didn't 12 students in the control group chose .accept instructor-led training model well. There was groups in students' attitudetive to carry out self-led CPR training for nursing undergraduate (P<0.001).students, and Conclusion  It is feasible and effec it is generally accepted. But whether it is suitable for nursing interns at other levels of education requires further research.