Abstract: Objectives To construct evidence-based practice program of enteral feeding implementation process for critically ill patients based on guidelines in order to ensure the effective implementation of the guidelines in clinical practice，promote the scientific and standardized implementation process of enteral feeding and nursing for critically ill patients. Methods In this study，we used the Johns Hopkins evidence-based nursing implementation and transformation model as a guide.Baseline survey was performed to establish clinical issues and an evidence- based practice team was built to retrieve，screen，appraise guidelines and review criteria and methods. Obstacles to implementation of guidelines were analyzed based on review results after baseline review and the corresponding action strategy was formulated and made concretely. Eventually the evidence-based practice strategy was developed and fit for clinical situations. Results This study included 5 guidelines，and the program contents included evaluation of the risk of enteral feeding and nutritional status in critically illpatients，etc. Conclusion Constructing an evidence-based practice program based on guidelines can provide reference for standardizing the enteral feeding process of critically ill patients. It is the premise and guarantee for the clinical transformation and application of evidence.

Key words: Critical Illnes, Enteral Nutrition, Nursing Protocols, Guidebooks, Evidence-Based Practice