Abstract:

Objective To retrieve and evaluate literature on the management of mechanical ventilation in patients with sepsis，summarize the findings，and provide an evidence-based basis for clinical nursing practice. Methods Based on the 6S evidence resource pyramid model，relevant literature on the management of mechanical ventilation in patients with sepsis was searched from computerized decision-making systems，guideline websites，professional society websites，evidence-based databases，and original research databases，with the search period ranging from the inception of the database to August 3，2025. Three Researchers screened and evaluated the included literature to extract relevant evidence. Results 14 articles were included，comprising 6 guidelines，2 clinical decisions，5 expert consensuses，and a systematic review. Thirty-two best practice recommendations were synthesized across five aspects：timing of initiation，monitoring and assessment，oxygenation goals，ventilation strategies，and precautions，respectively. Conclusion This study provides a summary of the best evidence for the nursing management of mechanical ventilation in patients with sepsis. It offers an evidence-based foundation for healthcare professionals to develop standardized and effective nursing interventions and facilitate the early recovery of patients with sepsis.

Key words: Sepsis, Mechanical Ventilation, Nursing Management, Evidence-Based Nursing, Evidence Su-mmary