Objective To evaluate the implementation effect of an early activity multidisciplinary collaboration model based on the framework of the interprofessional collaborative team development theory in ICU mechanically ventilated patients. Methods Critically ill patients who received mechanical ventilation treatment in the Department of Intensive Care Medicine of a tertiary-level A hospital from July 2023 to February 2024 were selected as the study subjects using quasi-experiment research method，and were divided into 54 cases in the experimental group and 56 cases in the control group according to the sequence of admission time. The experimental group implemented the multidisciplinary cooperation mode of early activity based on the interprofessional collaborative team development theory，and the control group implemented the routine early activity program. The differences between the groups before and after intervention were compared in the level of cooperation of multidisciplinary team members，the rate of early activity among patients，the cumulative activity duration during ICU，the incidence of adverse events，the time of first active activity，the rate of out-of-bed activity，and the length of mechanical ventilation. Results The team cooperation level of multi-disciplinary members in experimental group was improved from（3.32±0.71） points to（3.72±0.50） points（P<0.01）. The early activity rate of experimental group was increased （The rates in experimental and control group were 48.21% and 35.22%）（P<0.05）The out-of-bed activity rate of experimental group was increased（The rates in experimental and control group were 48.1% and 7.1%）（P<0.01）. The cumulative activity time of patients during ICU stay was increased（P<0.05），and the length of mechanical ventilation was shortened（P<0.05）. There were no significant adverse events between the two groups during the activity period，and there was no significant difference in the time of the first active activity（P>0.05）. Conclusion The multidisciplinary collaboration model of early activity based on the theory of interprofessional collaborative team development may improve the cooperation level of multidisciplinary team members，promote the early activity of mechanical ventilation patients，and improve the efficiency of activity.
