Objective To evaluate the effects of a relocation stress nursing program on the coping relocation stress of family members of patients with severe traumatic brain injury(STBI) transferred from ICU. Methods A total of 108 family members of patients who met the inclusion and exclusion criteria and were transferred out of the ICU in a tertiary general hospital in Shanghai from August 2022 to July 2023 were selected as study subjects. 54 family members from February 2023 to July 2023 were assigned to the experimental group,and 54 family members from August 2022 to January 2023 were assigned to the control group. The control group received routine care,while the experimental group received the relocation stress nursing program. Differences in relocation stress levels,social support levels,coping styles,and caregiving abilities between the two groups were compared. Results After the intervention,the experimental group showed significantly better relocation stress levels,social support levels,coping styles,and caregiving abilities compared to the control group,with statistically significant differences(P<0.001). Conclusion The relocation stress nursing program developed in this study effectively reduced the relocation stress levels of family members,improved their coping styles,increased their social support levels and caregiving abilities,thereby creating a more favorable family support environment for patient recovery.