eISSN 2097-6046
ISSN 2096-7446
CN 10-1655/R
Responsible Institution：China Association for Science and Technology
Sponsor：Chinese Nursing Association
中华急危重症护理杂志

Chinese Journal of Emergency and Critical Care Nursing ›› 2026, Vol. 7 ›› Issue (4): 459-461.doi: 10.3761/j.issn.2096-7446.2026.04.013

• Critical Care Research • Previous Articles     Next Articles

Perioperative nursing care of a child with liver-brain-type mitochondrial DNA depletion syndrome undergoing liver transplantation

TANG Wenxiu1(), YING Yan1, ZHU Jihua2,*(), GE Hongling1, ZHOU Weiwei1   

  1. 1 General Surgery Department/Hepatobiliary Surgery Center， Children’s Hospital Zhejiang University School of Medicine/National Clinical Medical Research Center for Children and Adolescents’ Health and Diseases， Hangzhou 310052， China
    2 Nursing Department， Children’s Hospital Zhejiang University School of Medicine/National Clinical Medical Research Center for Children and Adolescents’ Health and Diseases， Hangzhou 310052， China
  • Received:2025-06-23 Online:2026-04-10 Published:2026-04-02
  • Contact: ZHU Jihua E-mail:twx9408@zju.edu.cn;jihuazhu@zju.edu.cn

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Abstract:

To summarize the perioperative nursing experience of a child with liver-brain-type mitochondrial DNA depletion syndrome undergoing liver transplantation. Given the child’s energy synthesis abnormalities and metabolic disorders，the risk of metabolic storm before surgery，instability in hemodynamics and increased risk of hypothermia during the operation，as well as complex and diverse postoperative complications，the following measures were taken. A reasonable fasting strategy was developed preoperatively. Monitoring of hemodynamics was enhanced and hypothermia prevention measures were implemented intraoperatively. Postoperatively，a low-dose titration method for medication was adopted to accurately adjust drug doses and fluid strategy was dynamically adjusted to manage refractory ascites，and the individualized follow-up was conducted. After careful treatment and nursing，the child was discharged on the 38th day after the liver transplantation. After 6 months of outpatient follow-up，he recovered well.

Key words: Mitochondrial DNA Depletion Syndrome, Liver Transplantation, Perioperative Nursing, Pediatric Nursing