Abstract:

Objective To systematically review and meta-analyze the influencing factors of sleep disorders in post-ICU patients. Methods We searched related literature on influencing factors of sleep disorders in post-ICU patients in CNKI，Weipu Database，Wanfang Database，SinoMed，PubMed，Embase，CINAHL，Cochrane Library，and Web of Science，the retrieval time was from inception of the database to August 31，2024. All analyses were performed using Stata version 18.0. Results A total of 9 studies，involving 6 558 patients and 19 influencing factors，met the inclusion criteria. Nine influencing factors were pooled for meta-analysis. The identified significant risk factors included length of ICU stay（OR=1.136），comorbidity（OR=2.257），depression（OR=1.497），and pain（OR=1.121）. Significant protective factors included physical health（OR=0.897；MD=7.483），and mental health （OR=0.845；MD=7.993）. The remaining influencing factors，which could not be pooled，were systematically reviewed. The risk factors included Acute Physiology and Chronic Health Evaluation（APACHE） Ⅱ score，tracheotomy，post-traumatic stress disorder（PTSD），ICU infections，serum cannabinoid levels，and drug abuse. Protective factors included the number of invasive tube removals at ICU discharge，serum melatonin levels，age，and ward sleep quality. Conclusion Sleep disorders in post-ICU patients are influenced by various factors，including therapeutic，physiological，and psychological aspects. Doctors and nurses should evaluate the sleep status of post-ICU patients as early as possible，comprehensively，and dynamically，providing individualized and precise prevention and intervention measures. However，due to limitations in the quantity and quality of the included studies，some findings require further verification through higher-quality research in the future.

Key words: Post-ICU Patients, Sleep Disorders, Influencing Factors, Systematic Review, Meta-Analysis, Evidence-Based Nursing