Abstract:

Objective To systematically evaluate the effect of high-1low nasal cannula oxy gen therapy after extubation in patients undergoing mechanical ventilation. Methods We searched Cochrane Library , Joanna Briggs Institute Library (JBI), Pubmed ,MEDLIN E, Embase ,CINAHL,CNKI, VIP Database , China Biomedical Literature Database (CBM) and W anfang Database for randomized controlled trials on the effects of high-flow nasal catheter oxygen therapy after extubation in patients undergoing mechanical ventilation. After screening the literature , extracting data and evaluating literature quality , RevMan 5.3 software was used for meta-analysis. Results A total of 14 randomized controlled trials and 3, 375 patients were included. Meta-analysis showed that high-flow nasal catheter oxygen therapy had no advantage in reducing patient reintubation rate[ 95%Cl(0.52, 1.22) ,Z= 1.03, P=0.30], reducing patient mortality[95%CI(0.79, 1.56), Z=0.61 ,P=0.45],shortening the ICU length of stay[95%CI(-1.53, 1.27) ,Z=0.18, P=0.86] and .the incidence of spittoon [95%CI (0.01,1 .88),Z=1.47 ,P=0.14],and had some effects in reducing the incidence of pulmonary infection. Conclusion Compared with conventional oxygen therapy , nasal high-flow oxygen therapy can reduce the incidence of pulmonary infection,but it cannot reduce the patient's re intubation rate, ICU mortality incidence of spittoon and the ICU length of stay.

Key words:

Nasal Catheter Oxygen Inhalation, High-flow Oxygen Therapy, Mechanical Ventilation;Extubation;Meta-analysis