Abstract: Objective To apply the best evidence of central venous catheter (CVC)maintenance techniques in ICU adult critical patients，in order to improve ICU nurses’ compliance of evidence practice and reduce infection rate of central line-associated bloodstream infections(CLABSI). Methods Summary the evidences by the method of evidence-based nursing and apply them after indigenization. Nursing records，field observation and questionnaire were used to collect the data. The evidence application time was from February 2019 to August 2019. A total of 312 ICU patients and 62 ICU nurses were included in the study. Two rounds of quality reviews were conducted to analyze the obstacles in the application of evidence and figure out available resources and solutions. The rate of CLABSI of ICU adult critical patients，ICU nurses’ compliance with evidence practice and knowledge of CVC main-tenance were compared before and after the application of evidence. Results After the best evidence application， the CLABSI rate of ICU adult critical patients decreased from 3.71译 to 1.22译. 14 indicators with low compliance in CVC maintenance evidence review were significantly improved (P<0.05). ICU nurses’ knowledge of evidence-based CVC catheter maintenance was statistically improved(P<0.05). Conclusion Applying the best evidence to clinical nursing practice can promote the prevention and control of CLABSI in ICU adult critical patients and re-duce infection rate. It also can improve the nurses’ compliance of evidences and improve the quality of clinical nursing.

Key words: Critical Illnes, Catheterization, Central Venous, Intensive Care Units, Catheter-Related Infec- tions, Evidence-Based Practice