长新冠综合征患者疲劳管理的研究进展

doi:10.3761/j.issn.2096-7446.2025.01.020

摘要/Abstract

摘要：

尽管新型冠状病毒（COVID-19）的流行趋势总体趋于缓和，但解决长新冠疲劳给新冠康复者带来的长期健康问题仍十分迫切。该文综述了长新冠疲劳的概念、特征、评估和干预方法等内容，长新冠疲劳具有发病高、症状持续时间长、发病机制复杂、重症患者风险高、危害严重等特征；建议结合多维主观评估工具，以及身体、认知测试等客观疲劳评估工具进行综合评估；主要干预措施包括运动锻炼、营养支持、芳香疗法和认知行为干预。

关键词: 长新冠综合征, 疲劳, 病毒感染, 护理, 综述文献（主题）

Abstract:

Although the COVID-19 epidemic is generally subsiding，there remains an urgent imperative to address the long-term health issues faced by patients with long COVID fatigue. This paper provides a review of the concept，characteristics，evaluation methods，and intervention strategies pertaining to long COVID fatigue. The characteristics of long COVID fatigue include high incidence，long duration of symptoms，complex pathogenesis，high risk in severe patients，and serious harm. It is recommended to comprehensively evaluate long COVID fatigue by combining multi-dimensional subjective assessment tools and objective fatigue assessment tools such as physical and cognitive tests. Interventions for long COVID fatigue include exercise，nutritional support，aromatherapy，and cognitive behavioral intervention.

Key words: Long COVID Syndrome, Fatigue, Viral Infection, Nursing Care, Review Literature as Topic

邓雨阳, 段世杰, 张小燕, 罗琳, 丁蕾, 陈珊珊. 长新冠综合征患者疲劳管理的研究进展[J]. 中华急危重症护理杂志, 2025, 6(1): 120-123.

DENG Yuyang, DUAN Shijie, ZHANG Xiaoyan, LUO Lin, DING Lei, CHEN Shanshan. Research progress on fatigue management in patients with long COVID syndrome[J]. Chinese Journal of Emergency and Critical Care Nursing, 2025, 6(1): 120-123.

参考文献 31

[1]	Venkatesan P. NICE guideline on long COVID[J]. Lancet Res-pir Med, 2021, 9(2):129.
[2]	Chen C, Haupert SR, Zimmermann L, et al. Global prevalence of post-coronavirus disease 2019(COVID-19) condition or long COVID:a meta-analysis and systematic review[J]. J Infect Dis, 2022, 226(9):1593-1607.
[3]	Ceban F, Ling SS, Lui LMW, et al. Fatigue and cognitive im-pairment in Post-COVID-19 Syndrome:a systematic review and meta-analysis[J]. Brain Behav Immun, 2022,101:93-135.
[4]	Lopez-Leon S, Wegman-Ostrosky T, Perelman C, Sepulveda R, Rebolledo PA, Cuapio A, Villapol S. More than 50 long-term effects of COVID-19:a systematic review and meta-analysis[J]. Sci Rep, 2021, 11(1):16144. doi: 10.1038/s41598-021-95565-8 pmid: 34373540
[5]	Nabavi N. Long covid:how to define it and how to manage it[J]. BMJ, 2020,370:m3489.
[6]	Szabo S, Zayachkivska O, Hussain A, et al. What is really ‘Long COVID’?[J]. Inflammopharmacology, 2023, 31(2):551-557.
[7]	Ji GH, Chen C, Zhou MY, et al. Post-COVID-19 fatigue among COVID-19 in patients discharged from hospital:a meta-analysis[J]. J Infect, 2022, 84(5):722-746.
[8]	Alkodaymi MS, Omrani OA, Fawzy NA, et al. Prevalence of post-acute COVID-19 syndrome symptoms at different follow-up periods:a systematic review and meta-analysis[J]. Clin Microbiol Infect, 2022, 28(5):657-666.
[9]	张允旭, 鞠萍, 刘琪, 等. 新型冠状病毒感染后综合征的研究进展[J]. 中国感染控制杂志, 2023, 22(9):1114-1120.
	Zhang YX, Ju P, Liu Q, et al. Research progress in post-COVID-19 syndrome[J]. Chin J Infect Contr, 2023, 22(9):1114-1120.
[10]	Huang CL, Huang LX, Wang YM, et al. 6-month consequences of COVID-19 in patients discharged from hospital:a cohort study[J]. Lancet, 2023, 401(10393):e21-e33.
[11]	深圳市第三人民医院, 国家感染性疾病临床医学研究中心,深圳市感染性疾病质量控制中心. 长新冠综合征临床诊治专家共识[J]. 中华临床感染病杂志, 2023, 16(6):427-445.
	Shenzhen Third People’s Hospital, National Clinical Research Center for Infectious Diseases, Shenzhen Infectious Disease Quality Control Center. Expert consensus on the diagnosis and treatment of long COVID syndrome[J]. Chin J Clin Infect Dis, 2023, 16(6):427-445.
[12]	Premraj L, Kannapadi NV, Briggs J, et al. Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome:a meta-analysis[J]. J Neurol Sci, 2022, 434:120162.
[13]	Vercoulen JH, Swanink CM, Fennis JF, et al. Dimensional asse-ssment of chronic fatigue syndrome[J]. J Psychosom Res, 1994, 38(5):383-392. doi: 10.1016/0022-3999(94)90099-x pmid: 7965927
[14]	吴春薇, 刘占东, 张拥波, 等. 个人疲劳强度问卷中译本在脑梗死患者中的临床应用与评价[J]. 中国康复理论与实践, 2008(2):116-118.
	Wu CW, Liu ZD, Zhang YB, et al. Clinical application and assessment of Chinese Version of Checklist Individual Strength Questionnaire in stroke patients[J]. Chin J Rehabil Theory Pract, 2008(2):116-118.
[15]	Piper BF, Dibble SL, Dodd MJ, et al. The revised Piper Fatigue Scale:psychometric evaluation in women with breast cancer[J]. Oncol Nurs Forum, 1998, 25(4):677-684. pmid: 9599351
[16]	So WKW, Dodgson J, Tai JWM. Fatigue and quality of life among Chinese patients with hematologic malignancy after bone marrow transplantation[J]. Cancer Nurs, 2003, 26(3):211-219. pmid: 12832954
[17]	Smets EM, Garssen B, Bonke B, et al. The Multidimensional Fatigue Inventory(MFI) psychometric qualities of an instru-ment to assess fatigue[J]. J Psychosom Res, 1995, 39(3):315-325. doi: 10.1016/0022-3999(94)00125-o pmid: 7636775
[18]	Chuang LL, Chuang YF, Hsu MJ, et al. Validity and reliability of the Traditional Chinese version of the Multidimensional Fatigue Inventory in general population[J]. PLoS One, 2018, 13(5):e0189850.
[19]	Chalder T, Berelowitz G, Pawlikowska T, et al. Development of a fatigue scale[J]. J Psychosom Res, 1993, 37(2):147-153. doi: 10.1016/0022-3999(93)90081-p pmid: 8463991
[20]	杨婉凤, 黄凌鹰, 周振华, 等. 疲劳量表-14在慢性乙型肝炎患者中的信度与效度评价[J]. 上海中医药大学报, 2012, 26(4):33-36.
	Yang WF, Huang LY, Zhou ZH, et al. Estimation on reliability and validity of fatigue scale-14 in patients with chronic he-patitis B[J]. Acad J Shanghai Univ Tradit Chin Med, 2012, 26(4):33-36.
[21]	Calvo-Paniagua J, Díaz-Arribas MJ, Valera-Calero JA, et al. A tele-health primary care rehabilitation program improves self-perceived exertion in COVID-19 survivors experiencing Post-COVID fatigue and dyspnea:a quasi-experimental study[J]. PLoS One, 2022, 17(8):e0271802.
[22]	Razazian N, Kazeminia M, Moayedi H, et al. The impact of physical exercise on the fatigue symptoms in patients with multiple sclerosis:a systematic review and meta-analysis[J]. BMC Neurol, 2020, 20(1):93. doi: 10.1186/s12883-020-01654-y pmid: 32169035
[23]	郑春辉, 刘飞, 房晶, 等. 新型冠状病毒感染后综合征的营养干预研究进展[J]. 山东医药, 2023, 63(22):102-106.
	Zheng CH, Liu F, Fang J, et al. Research progress on nutritio-nal intervention of post-infection syndrome in novel corona-virus[J]. Shandong Med J, 2023, 63(22):102-106.
[24]	Venturini L, Bacchi S, Capelli E, et al. Modification of immu-nological parameters,oxidative stress markers,mood symptoms,and well-being status in CFS patients after probiotic intake:observations from a pilot study[J]. Oxid Med Cell Longev, 2019, 2019:1684198.
[25]	Rathi A, Jadhav SB, Shah N. A randomized controlled trial of the efficacy of systemic enzymes and probiotics in the reso-lution of post-COVID fatigue[J]. Medicines, 2021, 8(9):47.
[26]	尚娅萌, 刘芳丽, 李佳欣, 等. 间质性肺疾病患者疲劳管理的研究进展[J]. 中华护理杂志, 2023, 58(15):1821-1825. doi: 10.3761/j.issn.0254-1769.2023.15.005
	Shang YM, Liu FL, Li JX, et al. Research review of fatigue recognition and management in patients with interstitial lung disease[J]. Chin J Nurs, 2023, 58(15):1821-1825. doi: 10.3761/j.issn.0254-1769.2023.15.005
[27]	Zamanifar S, Bagheri-Saveh MI, Nezakati A, et al. The effect of music therapy and aromatherapy with chamomile-lavender essential oil on the anxiety of clinical nurses:a randomized and double-blind clinical trial[J]. J Med Life, 2020, 13(1):87-93. doi: 10.25122/jml-2019-0105 pmid: 32341707
[28]	陈英, 陈晓洁, 王舒洁, 等. 芳香疗法联合情绪释放技术对失眠乳腺癌患者影响的研究[J]. 中华护理杂志, 2022, 57(6):651-658. doi: 10.3761/j.issn.0254-1769.2022.06.002
	Chen Y, Chen XJ, Wang SJ, et al. Effect of lavender aromatic therapy combined with emotional freedom techniques on inso-mnia cancer breast patients with heart and spleen deficiency[J]. Chin J Nurs, 2022, 57(6):651-658.
[30]	Thoma N, Pilecki B, McKay D. Contemporary cognitive beha-vior therapy:a review of theory,history,and evidence[J]. Psy-chodyn Psychiatry, 2015, 43(3):423-461.
[31]	Kahlmann V, Moor CC, van Helmondt SJ, et al. Online mind-fulness-based cognitive therapy for fatigue in patients with sarcoidosis(TIRED):a randomised controlled trial[J]. Lancet Respir Med, 2023, 11(3):265-272.