浆细胞疾病患者行嵌合抗原受体T细胞免疫治疗并发细胞因子释放综合征的护理

doi:10.3761/j.issn.2096-7446.2025.10.012

中华急危重症护理杂志 ›› 2025, Vol. 6 ›› Issue (10): 1220-1222.doi: 10.3761/j.issn.2096-7446.2025.10.012

浆细胞疾病患者行嵌合抗原受体T细胞免疫治疗并发细胞因子释放综合征的护理

李影(), 朱岩, 曾妃

310000 杭州市浙江大学医学院附属第二医院滨江综合ICU

收稿日期:2024-11-25 出版日期:2025-10-10 发布日期:2025-09-25
作者简介:李影：女，本科，主管护师，E-mail：1197991621@qq.com

Nursing care for a patient with plasma cell disease undergoing chimeric antigen receptor T-cell immunotherapy complicated with cytokine release syndrome

LI Ying(), ZHU Yan, ZENG Fei

Received:2024-11-25 Online:2025-10-10 Published:2025-09-25

摘要/Abstract

摘要：

总结1例浆细胞疾病患者行嵌合抗原受体T细胞免疫治疗后并发细胞因子释放综合征的护理体会。针对患者出现的意识淡漠、畏寒高热、血压下降、三系血细胞减少等临床表现，采取严密病情监测、及时启动应急预案、循环支持、连续性肾脏替代治疗、感染预防等综合护理措施，患者成功救治并顺利出院，随访生活质量良好。

关键词: 嵌合抗原受体T细胞疗法, 细胞因子释放综合征, 危重病护理

Abstract:

This article summarized the nursing experience of a patient with plasma cell disease who developed cytokine release syndrome（CRS） following chimeric antigen receptor T-cell（CAR-T） therapy. The patient exhibited severe clinical manifestations of CRS，including altered mental status，chills with high fever，hypotension，and pancytopenia. A comprehensive nursing approach was implemented，which included rigorous monitoring of the patient’s condition，prompt initiation of emergency response protocols，circulatory support，continuous renal replacement therapy（CRRT），and infection prevention. As a result of these measures，the patient was successfully treated and discharged. Follow-up revealed that the patient had a good quality of life.

Key words: Chimeric Antigen Receptor T-cell Therapy, Cytokine Release Syndrome, Critical Care Nursing

李影, 朱岩, 曾妃. 浆细胞疾病患者行嵌合抗原受体T细胞免疫治疗并发细胞因子释放综合征的护理[J]. 中华急危重症护理杂志, 2025, 6(10): 1220-1222.

LI Ying, ZHU Yan, ZENG Fei. Nursing care for a patient with plasma cell disease undergoing chimeric antigen receptor T-cell immunotherapy complicated with cytokine release syndrome[J]. Chinese Journal of Emergency and Critical Care Nursing, 2025, 6(10): 1220-1222.

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浆细胞疾病患者行嵌合抗原受体T细胞免疫治疗并发细胞因子释放综合征的护理

Nursing care for a patient with plasma cell disease undergoing chimeric antigen receptor T-cell immunotherapy complicated with cytokine release syndrome

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