Objective This study aims to construct an analgesia and sedation management program for adult patients undergoing extracorporeal membrane oxygenation（ECMO） therapy in order to prevent the accumulation of analgesics and sedatives，avoid inadequate analgesia and sedation，reduce adverse events，and optimize ECMO support. Methods By searching domestic and foreign literature，obtaining best practice evidence，we constructed the first draft of an adult extracorporeal membrane oxygenation analgesia and sedation management program. From March to May 2024，16 experts were consulted for 2 rounds using the Delphi method to form the final draft of the adult ECMO analgesia and sedation management program. Convenience sampling method was used to select ECMO patients from the critical care medicine department of a tertiary A hospital in Shenzhen from July to September 2024 for preliminary application. The Critical-Care Pain Observation Tool（CPOT） and the Richmond Agitation and Sedation Scale（RASS） evaluation scales were used to evaluate the analgesia and sedation effect of the patients after application of the program. Results The effective questionnaire recovery rate for the two rounds of Delphi consultation were 88.9% and 100%，respectively. The expert authority coefficient was 0.862 and Kendall’s coordination coefficient was 0.069 and 0.085（both P<0. 001）. The sedation and analgesia management program in ECMO therapy for adult patients was finally formed，including 5 primary indicators（assessment tools，analgesia and sedation goals，drug selection，drug titration，monitoring），11 secondary indicators，and 24 tertiary indicators. After application of this program，the CPOT score was <3 points，the patient had no adverse stimulation that caused by pain，and the RASS score was -3 to 1. The patient did not experience insufficient or excessive sedation，and an appropriate level of sedation was maintained. Conclusion The adult ECMO analgesia and sedation management program constructed in this study is comprehensive，specific，scientific and feasible，and can provide reference for adult ECMO analgesia and sedation management.