To summarize the nursing experience of chimeric antigen receptor T-cell（CAR-T） immunotherapy in a child with systemic lupus erythematosus. The key nursing points included：setting up a multidisciplinary team before infusion to develop a personalized assessment scale and implement high risk prevention，precise reinfusion of CAR T-cells and close monitoring，strengthening the management of adverse reactions such as cytokine release syndrome and immune effector cell-related neurotoxic syndrome after infusion. At the same time，the team paied attention to children’s psychology and did fun narrative nursing. Through individualized treatment and nursing，the child’s condition was effectively controlled and discharged smoothly. Three months after transfusion，the disease activity index of systemic lupus erythematosus decreased to 0，and the 24-hour urine protein decreased to 62.5 mg.