Objective The study aims to establish a neuro-monitoring and nursing plan during the low perfusion period in emergency cardiac arrest patients based on appropriate use criteria，to address the problem of brain injury after autonomous circulation recovery. This plan provides guidance for clinical nurses on neurological management during low perfusion period in cardiopulmonary resuscitation patients. Methods This study established a multidisciplinary team to develop a neuro-monitoring and nursing plan for emergency cardiac arrest patients during the low perfusion period based on the AHA and ILCOR guidelines. A total of 68 patients in the experimental group were resuscitated according to the plan，while the control group followed the traditional cardiopulmonary resuscitation protocol. Results There was no statistically significant difference between the two groups in terms of patient age，gender，cause of cardiac arrest，and outcomes. The neurological function assessment in survivors of the experimental group was significantly better than that of the control group（P=0.017）. In patients who achieved ROSC in the experimental group，the changes in end-tidal CO2 and cerebral oxygen saturation were consistent with domestic and foreign studies，but due to the limited sample size，there is no statistically significant difference between the two groups. Conclusion The neuro-monitoring and nursing plan during the low perfusion period in emergency cardiac arrest patients holds promise for improving neurological outcomes after cardiopulmonary resuscitation. However，there are operational complexities and technical challenges during its implementation.