To summarize the nursing experience of a patient with severe hypothermia and third-degree frostbite caused by staying overnight in the wild after binge drinking in winter. Nursing priorities included gradient rewarming strategy（external electric blanket combined with continuous renal replacement therapy in vivo） to achieve core body temperature recovery within 7.25 h，frostbite wounds treated with moist burn ointment and silver sulfadiazine sequential therapy，combining sedation and analgesia with daily arousal strategies to manage impairment of consciousness. After 7 days of treatment，the patient was discharged from the hospital，and the function of the frostbitten limb was fully recovered two months later. It is suggested that for severe frostbite cases in non-cold areas，early and precise rewarming，wound stratification management，and comprehensive prevention and treatment of multi-system complications are the keys to successful treatment.