Objective To establish an information-based early warning system for post-pyloric enteral nutrition and evaluate its effect on enteral nutrition in patients with severe neurological diseases. Methods A multidisciplinary team was established to build an information-based early warning system for post-pyloric enteral nutrition based on aspiration risk assessment and nursing quality indicators. The system was used to warn the risk of aspiration and to remind the post-pyloric enteral nutrition. The differences in indicators related to post-pyloric enteral nutrition were compared between control group （June to December 2022） and experimental group （February to July 2023）. Results The incidence of aspiration pneumonia and the delay time of nasointestinal tube insertion were significantly lower than those in the control group after the implementation of the information-based early warning system（P<0.05）. The rate of post-pyloric feeding，the rate of timely nasointestinal catheterization and the re-evaluation timeliness rate of aspiration risk assessment in the experimental group were significantly higher than those in the control group（P<0.05）. There was no significant difference in the initial assessment timeliness rate of aspiration risk assessment and the implementation rate of early enteral nutrition（P>0.05）. Conclusion The establishment and implementation of the information-based early warning system for post-pyloric enteral nutrition is conducive to the early adoption of post-pyloric enteral nutrition in high-risk patients with aspiration as soon as possible. It can reduce the incidence of aspiration and aspiration pneumonia and ensure the safety of patients.