To summarize the emergency nursing experience for a child with febrile infection-related epilepsy syndrome（FIRES）. Due to the rapid and difficult-to-control progression in FIRES，and the high mortality rate associated with propofol infusion syndrome，optimal respiratory support was implemented to improve ventilation，dynamic adjustments of anesthetics were made，biologics used according to protocols，and early initiation of a ketogenic diet was employed to control acute seizures，measures such as extracorporeal membrane oxygenation （ECMO） and plasma exchange were utilized to maintain stable organ function，propofol infusion syndrome was cor-rected. After 35 days of meticulous treatment and care，the patient’s condition stabilized，overcoming the acute phase.