Objective To explore the effect of combined teaching method in standardized training of ICU nurses. Methods 40 standardized trained nurses rotating in ICU from February 2022 to February 2023 were set as the experimental group，and the combined teaching method was adopted. The 40 standardized trained nurses rotating in ICU from January 2021 to January 2022 were set as the control group，the traditional teaching method was used. Both groups were taught for 3 months. The results of theoretical assessment，skills assessment，nursing rounds and satisfaction of teaching were compared between the two groups after teaching，the scores of independent learning ability and post competency were compared before and after teaching. Results After teaching，the scores of theoretical，skills and nursing rounds of experimental group were higher than those of control group （t=2.580，P= 0.012；t=2.351，P=0.022；t=2.311，P=0.024）. The score of independent learning ability and the post competency of the experimental group were improved than that of the control group（t=3.426，P=0.001；t=5.411，P<0.001）. The teaching satisfaction of experimental group was higher than that of control group （t =2.847，P=0.006）. Conclusion The combined teaching methods can improve the comprehensive scores of ICU trained nurses，improve the independent learning ability and post competence level，and teaching satisfaction is high.