Objective To explore the effect of real-time feedback technology on improving the quality of external chest compression of rescuers wearing personal tertiary protective equipment. Methods Twenty medical staff in emergency department were selected as subjects by convenience sampling method. A pre-post self comparison design was used. Subjects wearing tertiary personal protective equipment first performed routine chest compressions without feedback on a cardiopulmonary resuscitation（CPR） simulator(the routine compression group). After full rest， external chest compressions under feedback were performed(the feedback compression group). The quality of external chest compressions and physiological indicators（including heart rate，systolic blood pressure，diastolic blood pressure， and blood oxygen saturation） before and after external chest compressions in the two groups were observed and recorded. Results The compression frequency of subjects in the routine compression group was （133±12） times per minute，which was higher than that in the feedback compression group （113 ±5），and the difference was statistically significant （P=0.001）. The pressing depth of the routine compression group was （4.5±1.0） cm，which was shallower than that of the feedback compression group （5.8 ±0.8） cm，and the difference was statistically significant （P=0.027）. The comprehensive compliance rate of the routine compression group was only 6.2%，which was significantly lower than 91% in the feedback compression group，and the difference between the two groups was statistically significant（P=0.001）. There was no significant difference in the physiological index data between the two groups before and after chest compression （P>0.05）. Conclusion Real-time feedback technology can effectively improve the quality of external chest compression of rescuers wearing personal three-level protection equipment and has no effect on the physiological indicators of rescuers.