To report on the nursing experience of a middle-aged foreign male patient with Tropheryma whipplei pneumonia. The incidence rate of the disease in Europe is only three per million，and it is even rarer in China. The patient’s condition worsened gradually after onset and was treated at two hospitals in Yunnan Province. In addition，differences in medical system，culture，habits，and other factors increased the difficulty of nursing. The nursing focus included oxygen therapy care，infection prevention care，fever care mainly focused on physical cooling， customized dietary plans based on patient needs，family participatory care，skin care，medication care，cross-cultural care，and follow-up management. After treatment and care，the patient’s condition improved steadily and was discharged from the hospital. The patient’s condition did not worsen further during follow-up calls.