This study summarized nursing experience of a patient with Stanford type A aortic dissection，who suffered from skin failure and mucosal injury after surgery. The patients had acute skin failure，diffuse gastrointestinal mucosal injury，and oral and nasal mucosa instrument-related pressure injury. Throughout the nursing process，we identified and addressed relevant risk factors in a timely manner，and implemented a phased turnover strategy to optimize the skin care program.，offered customized nutritional plans and specialized care for managing incontinence- related dermatitis，prioritized the protection of the oral and nasal mucosa to prevent device-related pressure injuries. Following 53 days of treatment in ICU，the patient had significant improvement in the condition of skin and mucosa，and was discharged from the hospital on the 70th day post-surgery.