To summarize nursing experience of risk management for 12 patients with pulmonary alveolar proteinosis undergoing whole lung lavage based on Hall’s three-dimensional model. According to the particularity of the disease and the multiple risks of whole lung lavage，the risk of patients was graded and controlled，and early warning was given. The Hall three-dimensional model was introduced to take the perioperative period of whole lung lavage as the axis，and the professional knowledge and logic thinking ability were used to systematically investigate and deal with risks and hidden dangers，so as to improve the safety nursing efficiency. The patients were hospitalized for 4-29 days and discharged after symptoms improved.