To summarize the emergency nursing experience of a patient with multiple organ dysfunction caused by oral tetrachloroethylene poisoning. Targeted nursing measures should be taken to address the multi-channel absorption of toxins and the rapid progression of the disease，including the need of rapid and thorough removal of toxins while protecting visceral functions， we adopted a sequential detoxification strategy combined digestive tract- respiratory tract-skin-visceral system，high tidal volume mechanical ventilation strategy to promote detoxification， dynamic evaluation of lung ultrasound to prevent barotrauma，and visualization of traditional Chinese medicine gastric lavage during mechanical ventilation to prevent aspiration. After comprehensive and efficient first aid and nursing through the integration of traditional Chinese and Western medicine，the patient’s condition improved and was discharged 6 days after admission. There were no abnormalities in the one-month follow-up after discharge.