Objective To describe the level of psychological resilience in ICU physically restrained patients and to explore the influencing factors. Methods A general information questionnaire，Connor-Davidson Resilience Scale， Social Support Rating Scale，General Self-Efficacy Scale，Medical Coping Modes Questionnaire，and the Chinese short version of the Eysenck Personality Questionnaire were used to investigate 301 physically restrained patients admit- ted to the Department of Intensive Care Medicine of a tertiary class A hospital in Fujian Province from December 2021 to December 2022. Structural equation modelling was used to conduct the path analyses for the various influ- encing factors. Results Total psychological resilience score of ICU physically restrained patients was （53.17 ± 17.41），self-efficacy score was （25.16±7.96），social support score was （38.93±15.12），medical coping total score was （44.15±15.21），and Eysenck's personality total score was （23.68±2.98）. The total psychological resilience score of ICU physically restrained patients was positively correlated with the total social support score （r=0.585，P<0.001）， positively correlated with the total self-efficacy score （r=0.545，P<0.01），positively correlated with the confrontation dimension of the medical coping styles （r=0.602，P<0.01），and negatively correlated with the yielding and avoidance dimensions （r=-0.567，P<0.01；r=-0.627，P<0.01），positively correlated with the introversion and extroversion dimen- sions of personality traits（r=0.326，P<0.01），and negatively correlated with neuroticism，psychoticism，and dissimulation scores （r=-0.395，P<0.01；r=-0.338，P<0.01；r=-0.362，P<0.01）. The model was well-fitted，social support had direct and indirect effects on psychological resilience（r=0.546，P<0.001；r=0.267，P<0.001），self-efficacy had a direct effect onpsychological resilience （ r=0.218，P<0.001）. Confrontation coping style had a direct positive effect on psychological resilience（ r=0.415，P<0.001），avoidance coping style had a direct negative effect（ r=-0.216，P=0.007） and resignation coping style had a direct negative effect on psychological resilience （ r=-0.431，P<0.001）. Personality traits had a significant negative effect on psychological resilience（r=-0.606，P<0.001）。 Conclusion The overall level of psychologi- cal resilience of ICU physical restraint patients is low. Social support，self-efficacy，coping styles，and personality traits are important influencing factors on the psychological resilience of ICU physical restraint patients. Improving the level of their psychological resilience can be approached from these four factors.