Objective To explore and evaluate the application effectiveness of Internet of Things（IoT） blood man- agement scheme. Methods Based on radio frequency identification technology （RFID），we developed intelligent blood refrigerators and IoT blood transfer boxes，automated intelligent blood（bank） management systems and closed- loop blood transfusion information management systems，an intelligent management system for ICU blood use was constructed to implement full-process informatization supervision and traceability management，and conduct dynamic regulation and evaluation for blood transfusion management of critically ill patients. We selected and compared the blood management data of critically ill patients before the application of intelligent blood management system（May 2021 to October 2021） and after the allocation（November 2021 to April 2022），and evaluated the role of this sys- tem in blood management in ICU. Results Before the application of IoT intelligent blood management scheme，a total of 2170 cases of blood use were used in 180 critically ill patients，and 3611 cases of blood use were used in 158 critically ill patients after the application. The non-cold chain time of blood bag decreased significantly from 8（5.5，15） min before implementation to 0.5（0.5，1） min after implementation. The average delivery time of each bag of blood decreased from 8（5.5，15） min before implementation to 1（0.5，1） min after implementation. The ICU pre- ventive blood preparation rate increased from 12.0%（260/2 170） before the implementation to 59.0%（2 130/3 611）.The qualified rate of medical record examination increased from 68.3% to 89.9%. The differences were statistically significant（P<0.001）. Conclusion The IoT intelligent blood transfusion scheme was helpful for the precise blood management for critically ill patients，improving the efficiency of blood use，and ensuring the ICU blood safety.