To summarize the nursing experience of a patient with severe burn complicated with Sheehan syndrome in stress state. In order to solve the problems of long duration of stress state，complex condition and difficult identification of complications in patients with extremely severe burn complicated with Sheehan syndrome， we set a reasonable target value of fluid resuscitation in shock stage to quickly and accurately correct shock and restore pituitary blood supply，set a value of blood cortisol to guide hormone replacement therapy to correct blood pressure，timely monitor the changes of body temperature and blood sodium to correct high fever，shorten the duration of stress state. We identified and deal with enteral nutritional intolerance during hospitalization，adopted sequential nutritional support methods to achieve the target feeding amount as soon as possible，and took double isolation measures to prevent drug-resistant bacteria infection. The wound healed and the patient was discharged on the 34th day after admission. We strengthened disease knowledge education and home safety education guidance before discharge，and followed up for one month. The patient recovered well.