To summarize the nursing care of a patient with prolonged venous sinus thrombosis treated with anticoagulation combined with intravascular therapy. In response to the preoperative increase in intracranial pressure，we adopted dynamic assessment and treatment of postoperative anticoagulation and bleeding risks，and nursing care of indwelling thrombolytic microcatheters in this patient，a dual track observation system，target oriented monitoring，and proper management of posture，skin，and activity during the indwelling thrombolytic microcatheters. After treatment and care，the patient recovered 9 days after thrombolysis and was discharged from the hospital. After 6 months of follow-up，there was no recurrence of venous sinus thrombosis.