Objective To investigate the application effect of self-made anti-skid counting grip dynamometer in grip strength exercise in ICU mechanically ventilated patients. Methods Anti-skid counting grip dynamometer consists of grip ball，gloves，flashing light，counter，convex ball，conductive rubber rod，convex particle and so on. 50 patients with mechanical ventilation from the Department of Critical Care Medicine of a tertiary hospital in Hangzhou from June to August 2022 were selected as application objects，and divided into control group and experimental group by the random number table method. 25 patients were in each group. The experimental group used the anti-skid counting grip dynamometer，and the control group used the traditional grip ball. The grip exercise compliance，grip strength，muscle strength of upper limbs，slippage times of grip balls and patient satisfaction were compared between two groups. Results The compliance of the experimental group was 96% which was higher than that in the control group （48%），and the difference was statistically significant （Z=-4.65，P< 0.05）. The increase of grip strength，muscle strength，and patient satisfaction in the experimental group were significantly higher than those in the control group （P<0.05）. The average slip times of the grip ball in the control group was 2.48 times，and there was no slip in the experimental group. Conclusion The application of anti-skid counting grip dynamometer in ICU mechanically ventilated patients can improve their compliance with grip strength exercise，thereby increasing their grip strength and muscle strength，and their satisfaction.