To summarize the nursing experience of a patient with neurogenic orthostatic hypotension and associated supine hypertension. To address the issues of the patient’s positional blood pressure changes，susceptibility to fall and lack of knowledge about multiple chronic diseases，measures such as multidisciplinary-green channel treatment，“position-volume-medication” pressure control，“feedforward-real time-emergency-feedback” whole-process fall prevention，“assessment-prescription-monitoring” personalized exercise rehabilitation and checklist-guided precision empowerment of health education were adopted. After 7 days of treatment and care，the patient’s condition stabilized and discharged from the hospital. After a 3-month follow-up after discharge，the patient’s condition was good.