eISSN 2097-6046
ISSN 2096-7446
CN 10-1655/R
Responsible Institution：China Association for Science and Technology
Sponsor：Chinese Nursing Association
中华急危重症护理杂志

Chinese Journal of Emergency and Critical Care Nursing >

2026 , Vol. 7 >Issue 3: 350 - 357

DOI: https://doi.org/10.3761/j.issn.2096-7446.2026.03.018

Eivdence Synthesis Research

Summary of the best evidence for prevention and management of alcohol relapse behavior in patients with alcoholic liver disease after liver transplantation

  • SUN Huihui ,
  • DING Jingping ,
  • ZHANG Yuxin ,
  • HAO Xiaochen ,
  • ZHANG Bingliang
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  • Department of Liver Transplantation， Affiliated Hospital of Qingdao University， Qingdao 266100， China

Received date: 2025-03-26

  Online published: 2026-03-02

Supported by

National Natural Science Foundation of China(81900575)

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Abstract

Objective To comprehensively search，evaluate and summarize the best evidence for prevention and management of alcohol relapse behavior in patients with alcoholic liver disease after liver transplantation，so as to provide a reference for clinical medical and nursing staff.Methods According to the 6S evidence model，domestic and foreign databases and websites were systematically searched for evidence on prevention and management of alcohol relapse behavior in patients with alcoholic liver disease after liver transplantation，including guidelines，clinical decisions，systematic reviews，evidence summaries，expert consensuses. The search time period was from the establishment of the database to August 1 2024. There were 2 researchers who evaluated the quality of the literature and extracted，evaluated，and integrated the evidence.Results A total of 12 articles were involved，including 2 clinical decision，5 clinical guidelines，1 expert consensus，4 systematic reviews，and 22 pieces of best evidence were summarized from 4 aspects，namely multidisciplinary team，evaluation and monitoring，preventive measures and non-drug interventions.Conclusion This study summarizes the best evidence for prevention and management of alcohol relapse behavior in patients with alcoholic liver disease after liver transplantation，so as to provide evidence-based basis for nursing practice. In the subsequent evidence translation process，it is essential to select evidence tailored to the specific clinical context in China，aiming to prevent alcohol relapse behavior of patients with alcoholic liver disease after liver transplantation and improve their clinical outcomes.

Key words： Liver Transplantation; Alcoholic Liver Disease; Alcohol Relapse; Evidence Summary; Evidence-Based Nursing

Cite this article

SUN Huihui , DING Jingping , ZHANG Yuxin , HAO Xiaochen , ZHANG Bingliang . Summary of the best evidence for prevention and management of alcohol relapse behavior in patients with alcoholic liver disease after liver transplantation[J]. Chinese Journal of Emergency and Critical Care Nursing, 2026 , 7(3) : 350 -357 . DOI: 10.3761/j.issn.2096-7446.2026.03.018

References

[1] Kim WR, Lake JR, Smith JM, et al. OPTN/SRTR 2015 annual data report:liver[J]. Am J Transplant, 2017, 17(Suppl 1):174-251.
[2] 贾欣宇, 朱青波, 贺田, 等. 酒精性肝病病人肝移植后酒瘾复发评估工具的研究进展[J]. 护理研究, 2024, 38(15):2696-2701.
  Jia XY, Zhu QB, He T, et al. Research progress of assessment tools for alcohol relapse in liver transplant recipients with alcoholic liver disease[J]. Chin Nurs Res, 2024, 38(15):2696-2701.
[3] Rice JP, Eickhoff J, Agni R, et al. Abusive drinking after liver transplantation is associated with allograft loss and advanced allograft fibrosis[J]. Liver Transpl, 2013, 19(12):1377-1386.
[4] Marot A, Moreno C, Deltenre P. Liver transplant for alcoholic hepatitis:a current clinical overview[J]. Expert Rev Gastroente-rol Hepatol, 2020, 14(7):591-600.
[5] 李天姿, 张慧芳, 黄月华, 等. 肝移植受者围手术期营养支持的最佳证据总结[J]. 中华急危重症护理杂志, 2024, 5(6):562-569.
  Li TZ, Zhang HF, Huang YH, et al. Summary of the best evi-dence of perioperative nutritional support for liver transplant recipients[J]. Chin J Emerg Crit Care Nurs, 2024, 5(6):562-569.
[6] AGREE Next Steps Consortium. The AGREE Ⅱ instrument[EB/OL].(2017-11-30)[2022-04-01]. https://www.agreetrust.org/wpcontent/uploads/2017/12/AGREE-II-Users-Manual-and-23-item-Instrument-2009-Update-2017.pdf.
[7] 张方圆, 沈傲梅, 曾宪涛, 等. 系统评价方法学质量评价工具AMSTAR 2解读[J]. 中国循证心血管医学杂志, 2018, 10(1):14-18.
  Zhang FY, Shen AM, Zeng XT, et al. An introduction to AMSTAR 2:a critical appraisal tool for systematic reviews[J]. Chin J Evid Based Cardiovasc Med, 2018, 10(1):14-18.
[8] The Joanna Briggs Institute(JBI)[EB/OL].(2017-07-15)[2017-11-24]. http://joannabriggs.org/research/critical-appraisal-tools.html.
[9] 王春青, 胡雁. JBI证据预分级及证据推荐级别系统(2014版)[J]. 护士进修杂志, 2015, 30(11):964-967.
  Wang CQ, Hu Y. JBI evidence pre-classification and evidence rank system(2014 Edition)[J]. J Nurses Train, 2015, 30(11):964-967.
[10] Scott LF. Liver transplantation for alcohol associated liver di-sease[EB/OL].(2022-11-23)[2024-01-31]. https://www.uptoda-te.com/contents/zh-Hans/liver-transplantation-for-alcohol-associa-ted-liver-disease.
[11] Paul JG, Scott JC. Liver transplantation in adults long term management of transplant recipients[EB/OL].(2021-01-27)[2024-07-08]. https://www.uptodate.com/contents/zh-Hans/liver-transplantation-in-adults-long-term-management-of-transplant-re-cipients.
[12] Jophlin LL, Singal AK, Bataller R, et al. ACG clinical guide-line:alcohol-associated liver disease[J]. Am J Gastroenterol, 2024, 119(1):30-54.
[13] Wood E, Bright J, Hsu K, et al. Canadian guideline for the clinical management of high-risk drinking and alcohol use disorder[J]. CMAJ, 2023, 195(40):E1364-E1379.
[14] Louvet A, Trabut JB, Moreno C, et al. Management of alcohol-related liver disease:the French association for the study of the liver and the French alcohol society clinical guidelines[J]. Liver Int, 2022, 42(6):1330-1343.
[15] Addolorato G, Abenavoli L, Dallio M, et al. Alcohol associated liver disease 2020:a clinical practice guideline by the Italian association for the study of the liver(AISF)[J]. Dig Liver Dis, 2020, 52(4):374-391.
[16] 中华医学会,中华医学会杂志社,中华医学会消化病学分会, 等. 酒精性肝病基层诊疗指南(实践版·2019)[J]. 中华全科医师杂志, 2020, 19(11):997-1001.
  Chinese Medical Association,Chinese Medical Journals Pub-lishing House,Gastroenterology Branch of Chinese Medical Association, et al. Guideline for primary care of alcoholic liver disease(2019)[J]. Chin J Gen Pract, 2020, 19(11):997-1001.
[17] McPherson S, Armstrong MJ, Cobbold JF, et al. Quality stan-dards for the management of non-alcoholic fatty liver disease(NAFLD):consensus recommendations from the British Association for the Study of the Liver and British Society of Gastroenterology NAFLD Special Interest Group[J]. Lancet Ga-stroenterol Hepatol, 2022, 7(8):755-769.
[18] Chuncharunee L, Yamashiki N, Thakkinstian A, et al. Alcohol relapse and its predictors after liver transplantation for alco-holic liver disease:a systematic review and meta-analysis[J]. BMC Gastroenterol, 2019, 19(1):150.
[19] Schlagintweit HE, Lynch MJ, Hendershot CS. A review of be-havioral alcohol interventions for transplant candidates and recipients with alcohol-related liver disease[J]. Am J Trans-plant, 2019, 19(10):2678-2685.
[20] Ranasinghe I, Sin J, Norman I, et al. Predicting and preventing alcohol relapse in alcohol-related liver disease[J]. Br J Nurs, 2018, 27(4):190-196.
[21] Rustad JK, Stern TA, Prabhakar M, et al. Risk factors for al-cohol relapse following orthotopic liver transplantation:a sys-tematic review[J]. Psychosomatics, 2015, 56(1):21-35.
[22] Golfieri L, Gitto S, Vukotic R, et al. Impact of psychosocial status on liver transplant process[J]. Ann Hepatol, 2019, 18(6):804-809.
[23] Donnadieu-Rigole H, Olive L, Nalpas B, et al. Follow-up of alcohol consumption after liver transplantation:interest of an addiction team?[J]. Alcohol Clin Exp Res, 2017, 41(1):165-170.
[24] DiMartini A, Dew MA, Day N, et al. Trajectories of alcohol consumption following liver transplantation[J]. Am J Trans-plant, 2010, 10(10):2305-2312.
[25] De Gottardi A, Spahr L, Gelez P, et al. A simple score for predicting alcohol relapse after liver transplantation:results from 387 patients over 15 years[J]. Arch Intern Med, 2007, 167(11):1183-1188.
[26] Dew MA, DiMartini AF, Steel J, et al. Meta-analysis of risk for relapse to substance use after transplantation of the liver or other solid organs[J]. Liver Transpl, 2008, 14(2):159-172.
[27] Tandon P, Goodman KJ, Ma MM, et al. A shorter duration of pre-transplant abstinence predicts problem drinking after liver transplantation[J]. Am J Gastroenterol, 2009, 104(7):1700-1706.
[28] 段方方, 张欣雪, 刘晨, 等. 酒精性肝病患者肝移植后生存及再饮酒研究[J/OL]. 中国肝脏病杂志(电子版), 2021, 13(3):62-67.
  Duan FF, Zhang XX, Liu C, et al. Analysis of survival and relapse in patients who underwent liver transplantation for alcoholic liver diseases[J/OL]. Chin J Liver Dis Electron Ver-sion, 2021, 13(3):62-67.
[29] DeMartini KS, Schilsky ML, Palmer A, et al. Text messaging to reduce alcohol relapse in prelisting liver transplant candi-dates:a pilot feasibility study[J]. Alcohol Clin Exp Res, 2018, 42(4):761-769.
[30] Gitto S, Aspite S, Golfieri L, et al. Alcohol use disorder and liver transplant:new perspectives and critical issues[J]. Korean J Intern Med, 2020, 35(4):797-810.
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