To summarize the nursing experience of an extremely preterm infant born at 23+2 weeks with a birth weight of 500 grams who developed severe skin injury following surgery for spontaneous intestinal perforation. In response to challenges including postoperative wound exudation and hemorrhage，extensive skin injury，and lack of nursing experience，a multidisciplinary case management team was established to develop a wound care protocol，implement pre- and post-dressing pain assessments and management，implement strictly infection prevention measures. After 29 days of careful treatment and nursing care，the infant’s wounds achieved primary healing with no secondary infections. The infant was successfully discharged after 198 days of hospitalization.