This study conducted a retrospective analysis of clinical data from children with hypertrophic cardiomyopathy who underwent the modified extended Morrow procedure at a center between January 2023 and November 2024，to summarize the postoperative nursing experience. In response to the surgical complexity and the elevated risk of postoperative complications，nursing interventions were implemented，including strict monitoring of heart rate and rhythm after surgery and correcting of electrolyte imbalances，arrhythmia prevention through pacemakers or beta-blockers and calcium channel blockers；optimization of volume status guided by blood pressure，central venous pressure，and echocardiography findings to avert low cardiac output syndrome，enhancement of cardiac function with vasoactive agents；respiratory tract management during and after ventilator weaning to prevent post-cardiac surgery hypoxemia；ongoing assessment of drainage volume，stringent coagulation function monitoring and heightened awareness of bleeding events. Thanks to meticulous nursing interventions，all 24 children were safely discharged from the ICU，offering invaluable insights for perioperative nursing care in similar cases.