This paper summarized the postoperative nursing experience of a child with short bowel syndrome caused by a giant mesenteric lymphangioma who underwent small bowel transplantation. After the operation，on the basis of stabilizing perfusion in the early stage and preventing the risks of thrombosis and bleeding，aiming at the core difficulties such as infection prevention and control，monitoring of acute rejection reactions，management of the transplanted intestinal stoma，and nutritional support，the nursing team implemented “triple barrier” measures for infection prevention and control，the management of anti-rejection drug administration with the principle of “three fixation and one monitoring”，individualized nursing for child’s stoma，and a step-by-step nutritional support plan. The “five-in-one” integrated intervention strategy was adopted to prevent the pediatric post intensive care syndrome（PICS-p）. The child was successfully transferred out of the pediatric intensive care unit on the 28th day after the operation. After 5 months of follow-up，the child’s body weight increased by 25%，and the function of the transplanted intestine recovered well.