eISSN 2097-6046
ISSN 2096-7446
CN 10-1655/R
Responsible Institution：China Association for Science and Technology
Sponsor：Chinese Nursing Association
中华急危重症护理杂志

Chinese Journal of Emergency and Critical Care Nursing >

2025 , Vol. 6 >Issue 9: 1124 - 1130

DOI: https://doi.org/10.3761/j.issn.2096-7446.2025.09.018

Evidence Synthesis Research

Evidence summary for assessment and nursing care for chemotherapy-induced peripheral neuropathy

  • SONG Ping ,
  • HU Min ,
  • ZENG Jie
Expand

Received date: 2024-11-01

  Online published: 2025-09-02

Fold

Abstract

Objective To summarize the best evidence of the assessment and nursing care for chemotherapy-induced peripheral neuropathy（CIPN），so as to provide a reference for clinical practice. Methods The literature related to CIPN was systematically searched in domestic and foreign databases. The time limit for the literature search was from the January 1，2020 to December 31，2024. Results 20 pieces of literature were ultimately included，including 1 clinical decisional support，2 guidelines，5 expert consensuses，1 evidence summary，and 11 systematic reviews. Totally 22 pieces of evidence related to the assessment and nursing care for CIPN were summarized，including 6 topics：multidisciplinary collaboration，assessment of timing and content，prevention，medical-based intervention，non-pharmacological prevention，and health guidance. Conclusion It is recommended that when applying the evidence，healthcare professionals should adequately assess the risk of CIPN in patients according to their general condition，disease type，and chemotherapy regimen，take the correct preventive measures according to the type of chemotherapeutic agents，then formulate a suitable functional exercise program in combination with the patient’s physical condition，gait，and personal preference，and implement individualized lifestyle guidance.

Key words： Chemotherapy; Peripheral Neuropathy; Evidence-Based Nursing; Evidence Summary

Cite this article

SONG Ping , HU Min , ZENG Jie . Evidence summary for assessment and nursing care for chemotherapy-induced peripheral neuropathy[J]. Chinese Journal of Emergency and Critical Care Nursing, 2025 , 6(9) : 1124 -1130 . DOI: 10.3761/j.issn.2096-7446.2025.09.018

References

[1] 中国抗癌协会肿瘤支持治疗专业委员会, 中国抗癌协会肿瘤临床化疗专业委员会. 化疗诱导的周围神经病变诊治中国专家共识(2022版)[J]. 中华肿瘤杂志, 2022, 44(9):928-934.
  Neoplastic Supportive Care Committee of China Anti-Cancer Association,Cancer Clinical Chemotherapy Committee of China Anti-Cancer Association. Chinese expert consensus on the diagnosis and treatment of chemotherapy-induced peripheral neuropathy(2022 edition)[J]. Chin J Oncol, 2022, 44(9):928-934.
[2] D’Souza RS, Saini CD, Hussain N, et al. Global estimates of pre-valence of chronic painful neuropathy among patients with chemotherapy-induced peripheral neuropathy:systematic review and meta-analysis of data from 28 countries,2000-24[J]. Reg Anesth Pain Med, 2025:rapm-2024-106229.
[3] Klafke N, Bossert J, Kr?ger B, et al. Prevention and treatment of chemotherapy-induced peripheral neuropathy(CIPN) with non-pharmacological interventions:clinical recommendations from a systematic scoping review and an expert consensus process[J]. Med Sci, 2023, 11(1):15.
[4] Molinares D, Kurtevski S, Zhu YR. Chemotherapy-induced peri-pheral neuropathy:diagnosis,agents,general clinical presenta-tion,and treatments[J]. Curr Oncol Rep, 2023, 25(11):1227-1235.
[5] 别敏娟, 胡君娥, 向艳华, 等. 化疗所致周围神经毒性评估和管理的证据总结[J]. 中国临床护理, 2021, 13(9):552-557.
  Bie MJ, Hu JE, Xiang YH, et al. Evidences for the evaluation and management of chemotherapy-induced peripheral neuropa-thy[J]. Chin Clin Nurs, 2021, 13(9):552-557.
[6] Foster MJ, Shurtz S. Making the critical appraisal for summa-ries of evidence(CASE) for evidence-based medicine(EBM):critical appraisal of summaries of evidence[J]. J Med Libr Assoc, 2013, 101(3):192-198.
[7] Hoffmann-Eβer W, Siering U, Neugebauer EAM, et al. Guideline appraisal with AGREE Ⅱ:online survey of the potential influence of AGREE Ⅱ items on overall assessment of guide-line quality and recommendation for use[J]. BMC Health Serv Res, 2018, 18(1):14.
[8] 胡雁, 郝玉芳. 循证护理学[M]. 2版. 北京: 人民卫生出版社, 2018.
  Hu Y, Hao YF. Evidence-based nursing[M]. 2nd ed. Beijing: People’s Medical Publishing House, 2018.
[9] Pieper D, Buechter RB, Li L, et al. Systematic review found AMSTAR,but not R(evised)-AMSTAR,to have good measure-ment properties[J]. J Clin Epidemiol, 2015, 68(5):574-558.
[10] 王春青, 胡雁. JBI证据预分级及证据推荐级别系统(2014版)[J]. 护士进修杂志, 2015, 30(11):964-967.
  Wang CQ, Hu Y. JBI evidence pre-classification and evidence rank system(2014 Edition)[J]. J Nurses Train, 2015, 30(11):964-967.
[11] Lustberg MB. Prevention and treatment of chemotherapy-indu-ced peripheral neuropathy[EB/OL].(2024-09-23)[2025-01-01]. https://www.uptodate.cn/contents/prevention-and-treatment-of-che-motherapy-induced-peripheral-neuropathy.
[12] Loprinzi CL, Lacchetti C, Bleeker J, et al. Prevention and ma-nagement of chemotherapy-induced peripheral neuropathy in survivors of adult cancers:ASCO guideline update[J]. J Clin Oncol, 2020, 38(28):3325-3348.
[13] Jordan B, Margulies A, Cardoso F, et al. Systemic anticancer therapy-induced peripheral and central neurotoxicity:ESMO-EONS-EANO Clinical Practice Guidelines for diagnosis,pre-vention,treatment and follow-up[J]. Ann Oncol, 2020, 31(10):1306-1319.
[14] 霍介格. 化疗药物导致的周围神经病变中西医结合防治专家共识[J]. 中国肿瘤外科杂志, 2023, 15(6):521-530.
  Huo JG. Expert consensus on the prevention and treatment of chemotherapy-induced peripheral neuropathy by integrated Chinese and Western medicine[J]. Chin J Surg Oncol, 2023, 15(6):521-530.
[15] 中国中西医结合疼痛学会, 中国抗癌协会中西医整合专业委员会, 中国中医药研究促进会. 化疗所致周围神经病理性疼痛中西医诊治专家共识[J]. 中华肿瘤防治杂志, 2021, 28(23):1761-1767,1779.
  Chinese Association of Integrated Chinese and Western Medicine Pain,Integrated Chinese and Western Medicine Pro-fessional Committee of Chinese Anti-Cancer Association, China Traditional Chinese Medicine Research Promotion Association. Expert consensus on diagnosis and treatment of peripheral neuropathic pain caused by chemotherapy in traditional Chinese and western medicine[J]. Chin J Cancer Prev Treat, 2021, 28(23):1761-1767,1779.
[16] Zhang YH, Hu HY, Xiong YC, et al. Exercise for neuropathic pain:a systematic review and expert consensus[J]. Front Med, 2021, 8:756940.
[17] Nakagawa N, Yamamoto S, Hanai A, et al. Exercise interven-tion for the management of chemotherapy-induced peripheral neuropathy:a systematic review and network meta-analysis[J]. Front Neurol, 2024, 15:1346099.
[18] Tai HY, Lin L, Huang TW, et al. Efficacy of cryotherapy in the prevention of chemotherapy-induced peripheral neuropa-thy:a systematic review and meta-analysis[J]. Support Care Cancer, 2024, 32(7):48.
[19] Chang TW, Yang FY, Liu YC, et al. Gabapentinoids for che-motherapy-induced peripheral neuropathy:systematic review and meta-analysis[J]. BMJ Support Palliat Care, 2024, 14(3):269-278.
[20] Papadopoulou M, Stamou M, Bakalidou D, et al. Non-pharmaco-logical interventions on pain and quality of life in chemo-therapy induced polyneuropathy:systematic review and meta-analysis[J]. In Vivo, 2023, 37(1):47-56.
[21] 张莹, 李之华, 刘子晗. 运动疗法防治肿瘤患者化疗所致周围神经病变效果的Meta分析[J]. 现代临床护理, 2023, 22(5):72-79.
  Zhang Y, Li ZH, Liu ZH. Effectiveness of exercise therapy on prevention and treatment of chemotherapy-induced peripheral neuropathy in cancer patients:a Meta-analysis[J]. Mod Clin Nurs, 2023, 22(5):72-79.
[22] Wang M, Yin YH, Yang HL, et al. Evaluating the safety,feasi-bility,and efficacy of non-invasive neuromodulation techniques in chemotherapy-induced peripheral neuropathy:a systematic review[J]. Eur J Oncol Nurs, 2022, 58:102124.
[23] Lopez-Garzon M, Cantarero-Villanueva I, Postigo-Martin P, et al. Can physical exercise prevent chemotherapy-induced periphe-ral neuropathy in patients with cancer? A systematic review and meta-analysis[J]. Arch Phys Med Rehabil, 2022, 103(11):2197-2208.
[24] Li T, Park SB, Battaglini E, et al. Assessing chemotherapy-induced peripheral neuropathy with patient reported outcome measures:a systematic review of measurement properties and considerations for future use[J]. Qual Life Res, 2022, 31(11):3091-3107.
[25] Bailey AG, Brown JN, Hammond JM. Cryotherapy for the pre-vention of chemotherapy-induced peripheral neuropathy:a syste-matic review[J]. J Oncol Pharm Pract, 2021, 27(1):156-164.
[26] Jin YX, Wang YX, Zhang JY, et al. Efficacy and safety of acupuncture against chemotherapy-induced peripheral neuro-pathy:a systematic review and meta-analysis[J]. Evid Based Complement Alternat Med, 2020, 2020:88754.
[27] 赵顺莹, 徐哲, 刘婷, 等. 癌症患者对化疗致周围神经病变体验质性研究的系统评价[J]. 护理管理杂志, 2020, 20(5):339-344.
  Zhao SY, Xu Z, Liu T, et al. Systematic evaluation of the experience quality of chemotherapy-induced peripheral neuro-pathy in cancer patients[J]. J Nurs Adm, 2020, 20(5):339-344.
[28] Cheng HL, Molassiotis A. Longitudinal validation and compari-son of the Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life-Chemo-therapy-Induced Peripheral Neuropathy Questionnaire(EORTC QLQ-CIPN20) and the Functional Assessment of Cancer-Gy-necologic Oncology Group-Neurotoxicity subscale(FACT/GOG-Ntx)[J]. Asia Pac J Clin Oncol, 2019, 15(1):56-62.
[29] Petrioli R, Pascucci A, Francini E, et al. Neurotoxicity of FO-LFOX-4 as adjuvant treatment for patients with colon and gastric cancer:a randomized study of two different schedules of oxaliplatin[J]. Cancer Chemother Pharmacol, 2008, 61(1):105-111.
Options
Outlines

/

〈 〉