Abstract: Objective To systematically evaluate the risk prediction models of central venous catheter blockage. Methods The Cochrane Library，CINAHL，Embase，PubMed，Web of Science，Wanfang，VIP，Chinese Biomedical Literature Database（CBM） and CNKI were searched for the researches on the risk prediction models of central venous catheter blockage. The retrieval period was from the establishment of the database to June 9，2023.Two investigators independently screened the literature and extracted the data，and evaluated the quality. Results A total of seven studies on the risk prediction model for central venous catheter occlusion were included，and the area under the ROC curve ranged from 0.660 to 0.820. The predictors with the highest frequency were thrombus history，body massindex，D-dimer level，blood flow velocity，and catheter tip position. The risk of bias assessment showed that the included studies had high risk of bias，six studies had good applicability and the remaining one study had poor applicability，mainly due to insufficient sample size，no blinding method reported and no proper missing data handling. Conclusion The existing risk prediction models of central venous catheter blockage had high risk of bias. In the future，we should focus on the methodological details of the study design and the standardization of reporting，and multi-center and large sample studies should be carried out to further optimize and validate the model and improve the model performance.

Key words: Central Venous Catheter, Blockage, Prediction Model, Systematic Review, Evidence-Based Nursing