Abstract: Objective To develop and implement prone positioning program for awake patients,and explore the feasibility and effeteness of prone positioning in awake patients. Methods The multidisciplinary treatment team was set up to develop the prone positioning program,including treatment decision of awake prone position timing,prone positioning schedule making with patients,prone position safety and tolerance assessment,position replacement scheme to improve tolerance,individualized time accumulation system,and prone position knowledge education and psychological support. The preliminary application was carried out in awake COVID-19 patients admitted to a designated hospital in Fujian province in September 2021. Results 136 patients were treated with awake prone positioning program,the average duration were （11.95±2.47）h. The prone positioning tolerability scores were significantly improved one week after hospital admission（t=35.254,P<0.05）. 133 patients recovered and 3 patients（2.2%）developed to critical illness,the average of hospitalization length was （14.95±3.02）days without serious adverse events during prone positioning. The oxygenation index of patients were significantly improved（F=5.624,P<0.05）. Conclusion The awake prone positioning program based on multidisciplinary treatment team cooperation is feasible and practical,which can provide a reference for the improvement of lung ventilation in clinical practice.

Key words: Prone Position, Awake, Interdisciplinary Research, COVID-19, Critical Care Nursing