Abstract: Objective This study aims to construct a program for prone position ventilation in cardiovascular critical patients，and to provide scientific references for the safe and effective implementation of prone ventilation in these patients. Methods The study group searched domestic and international databases，guideline websites and professional websites to retrieve relevant literature，and then selected clinical experts for semi-structured interviews， the first draft of the program was formed based on the literature analysis and the interviews. Delphi technique method was used to modify，add or delete items，and then the final draft of the program was formed. Results 2 rounds of Delphi consultation were conducted among 15 experts，and the effective recovery rate of the questionnaire was 100%. The expert authority coefficient was 0.855，and the Kendall harmony coefficient after the second round of consultation was 0.236 （P <0.001）. The final draft of the program contained 25 items，the mean value of importance assignment of items was 4.27 ~5.00. Conclusion The program constructed in this study is scientific， specific and reliable，with reference significance for clinical implementation.

Key words: Cardiovascular Disease, Critical Care Nursing, Prone Position Ventilation