Abstract: The perioperative nursing experience of a premature infant with omphalocele，exstrophy of the bladder， imperforate anus and spinal defect complex（OEIS） was summarized. Nursing key points：preoperative nursing of ev- ersion cloacal mucosa；nursing after first stage anal anoplasty to avoid anal stenosis and incision infection；nursing care after second stage surgery，including management of drainage tube under plaster fixation of human position af- ter bladder exstrophy repair，observation of intraperitoneal high pressure，prevention of cast syndrome，stepwise pain management，postoperative skin management and incision care to promote postoperative recovery；discharge guidance and transitional care to improve the discharge readiness and home care capabilities of infant’s family. The infant recovered well and was discharged on the 49th day of admission.

Key words: Bladder Exstrophy； Anus, Imperforate； Pain, Postoperative； Perioperative Nursing； Pediatric Nursing