Abstract: Objective To investigate the status and influencing factors of pre-hospital time in patients with acute aortic dissection and to analyze the effect of prehospital time on the outcome at discharge. Methods A total of 251 patients with acute aortic dissection were recruited from March 2018 to May 2019 in the department of car-diac macrovascular surgery of a tertiary first-class hospital in Wuhan by convenient sampling，and those patients were all transferred from other hospitals. The self-designed demographic data collection table and pre-hospital time questionnaire were used to collect data and logistic regression was used to explore the influencing factors of pre-hospital time. Results The median prehospital time was 568.00 minutes，and multiple factors regression analysis showed that the symptoms of sweating，whether it was persistent pain，the reaction of bystander，the first hospital the patient reached，whether there was confirmed diagnosis before referral，the way of admission，the number of hospitals the patients were treated and referral distance were the factors influencing prehospital time of acute aortic dissec-tion patients（P<0.05）. Conclusion If the patients had symptoms of sweating and/or persistent pain，bystander re-action was accessing medical treatment，the first hospital was a tertiary hospital，the patients were diagnosed before the referral，admitted directly to the cardiovascular surgery department，then the pre-hospital time was relatively short. In addition，the more hospitals the patient was treated and the longer the referral distance，the longer the pre-hospital time. It is necessary to increase the identification ability of diseases in medical institutions and make early diagnosis，reduce the number of hospitals the patient was transferred. It is suggested that patients should be directly referred to the final department to reduce the pre-hospital time，and improve the outcome.

Key words: Aortic Diseases, Patient Transfer, Pre-hospital Time, Emergency Nursing