Abstract: Objective To construct a multi-disciplinary team （MDT） approach for extracorporeal cardiopulmonary resuscitation（ECPR） and evaluate its application. Methods An expert group discussion method was used to con- struct a MDT protocol for extracorporeal cardiopulmonary resuscitation. Using a convenience sampling method，35 patients who underwent ECPR from January 2020 to December 2021 were selected as the experimental group，and 32 patients who underwent ECPR from January 2018 to December 2019 were selected as the control group. The experimental group implemented the extracorporeal cardiopulmonary resuscitation MDT protocol on the basis of the conventional process and care，while the control group was given the conventional emergency receiving and nursing care. Compared the time spent on each session，48h return of spontaneous circulation rate，48h survival rate and in- hospital survival rate between the two groups of patients. Results 31 cases were collected in the experimental group and 27 cases in the control group. The time spent in each session was significantly lower in the experimen- tal group than that in the control group after the intervention，and the difference was statistically significant（P<0.001）. The 48h return of spontaneous circulation rate，48h survival rate and in-hospital survival rate were significantly higher than those in the control group，and the differences were statistically significant （P<0.05）. Conclusion The application of the MDT approach for extracorporeal cardiopulmonary resuscitation can shorten the resuscitation time of patients with extracorporeal cardiopulmonary resuscitation，promote medical and nursing cooperation，and improve the resuscitation success rate.

Key words: Extracorporeal Cardiopulmonary Resuscitation, Cooperative Behavior, Interdisciplinary Research, Emergency Nursing, Clinical Nursing Research