Abstract: Objective To explore the current situation of coping difficulties in mothers of premature infants in the neonatal intensive care unit（NICU） and analyze the influencing factors. Methods Using the convenience sampling method,a total of 200 mothers of premature infants were investigated by the general information questionnaire,Post-Discharge Coping Difficulty Scale-New Mother Form（PDCDS）,the Parent Perception of Uncertainty Scale（PPUS）,and Family APGAR Index（APGAR） in the NICU of a tertiary hospital in Nanning,Guangxi from October 2020 to August 2021. Results The total score of 200 mothers for coping difficulties was （6.82± 0.89）,the total score of disease uncertainty was （89.26± 8.69）,and the total score of family function was （6.59± 1.54）. Multiple linear regression analysis showed that monthly household income per capita,lack of information,and family dysfunction were the main influencing factors of coping difficulties in mothers of premature infants（P< 0.05）. Conclusion The coping difficulties among mothers of premature infants in NICU were in the middle level. Educational guidance should be strengthened for mothers of premature infants with low monthly family income,lack of information support and family dysfunction,so as to reduce their coping difficulties.

Key words: Infant, Premature, Mothers, Coping With Difficulties, Neonatal Intensive Care Units