化疗诱导的周围神经病变评估及护理的最佳证据总结

doi:10.3761/j.issn.2096-7446.2025.09.018

摘要/Abstract

摘要：

目的总结化疗诱导的周围神经病变（chemotherapy-induced peripheral neuropathy，CIPN）评估及护理的相关证据，为临床实践提供参考。方法系统检索国内外网站及数据库中CIPN相关文献，检索时限为2020年1月1日—2024年12月31日。结果最终纳入20篇文献，其中临床决策1篇、指南2篇、专家共识5篇、证据总结1篇、系统评价11篇。从多学科协作、评估时机与内容、预防、药物干预、非药物干预、健康指导6个方面对CIPN评估及护理的证据进行汇总，共得到22条证据。结论建议医护人员在应用证据时，根据患者一般情况、疾病种类、化疗方案充分评估患者发生CIPN的风险，基于化疗药物种类采取正确的预防措施，并结合患者体能状况、步态、个人偏好制订适合的功能锻炼计划，实施个体化生活方式指导。

关键词: 化疗, 周围神经病变, 循证护理学, 证据总结

Abstract:

Objective To summarize the best evidence of the assessment and nursing care for chemotherapy-induced peripheral neuropathy（CIPN），so as to provide a reference for clinical practice. Methods The literature related to CIPN was systematically searched in domestic and foreign databases. The time limit for the literature search was from the January 1，2020 to December 31，2024. Results 20 pieces of literature were ultimately included，including 1 clinical decisional support，2 guidelines，5 expert consensuses，1 evidence summary，and 11 systematic reviews. Totally 22 pieces of evidence related to the assessment and nursing care for CIPN were summarized，including 6 topics：multidisciplinary collaboration，assessment of timing and content，prevention，medical-based intervention，non-pharmacological prevention，and health guidance. Conclusion It is recommended that when applying the evidence，healthcare professionals should adequately assess the risk of CIPN in patients according to their general condition，disease type，and chemotherapy regimen，take the correct preventive measures according to the type of chemotherapeutic agents，then formulate a suitable functional exercise program in combination with the patient’s physical condition，gait，and personal preference，and implement individualized lifestyle guidance.

Key words: Chemotherapy, Peripheral Neuropathy, Evidence-Based Nursing, Evidence Summary

宋萍, 胡敏, 曾洁. 化疗诱导的周围神经病变评估及护理的最佳证据总结[J]. 中华急危重症护理杂志, 2025, 6(9): 1124-1130.

SONG Ping, HU Min, ZENG Jie. Evidence summary for assessment and nursing care for chemotherapy-induced peripheral neuropathy[J]. Chinese Journal of Emergency and Critical Care Nursing, 2025, 6(9): 1124-1130.

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