Abstract: Objective To evaluate the effect of comprehensive unit-based safety program（CUSP） coordinated with action strategy on reducing the incidence of central line associated blood stream infection（CLABSI） in ICU patients. Methods The CUSP coordinated with action strategy intervention program was developed to reduce CLABSI by identifying the existing problems related to the incidence of CLABSI in ICU. The program was continuously applied in ICU and the intervention measures were dynamically adjusted during the application process from July 2019 to June 2021. The incidence of CLABSI,nurses' knowledge and practice of CLABSI,the implementation rate of central venous catheter-related maintenance items and hand hygiene compliance were compared before（July 2017 to June 2019） and after the intervention（July 2019 to June 2021）. Results The incidence of CLABSI in 14 681 catheter days before intervention was 0.82‰,while the incidence of CLABSI in 15 055 catheter days after intervention was 0.27‰,with statistical significance（P<0.05）. Before the intervention the ICU nurses' knowledge,attitude and practice score of CLABSI was （96.84±8.00）,and the score was （99.35±7.96） after the intervention,the difference was statistically significant（t=-2.016,P<0.05）. The implementation rate of central intravenous catheter maintenance was 82.73% before intervention and 92.74% after intervention（ χ²=4.735,P<0.05）. The hand hygiene compliance rate was 51.21% before the intervention and 85.33% after the intervention（ χ²=26.563,P<0.05）. Conclusion The adoption of comprehensive unit-based safety program coordinated with action strategy can reduce the incidence of CLABSI,improve the knowledge and practice of CLABSI,the implementation rate of central venous catheter maintenance and hand hygiene compliance of ICU nurses.

Key words: Catheter-related Infections, Comprehensive Unit-based Safety Program, Action Strategy, Intensive Care Units, Nursing Administration Research