Abstract:

Objective This study aims to evaluate the effect of early mobilization in patients with extracorporeal membrane oxygenation（ECMO）. Methods The databases of CNKI，Wanfang，VIP，CBM，PubMed，Embase，Cochrane Library，and Web of Science were searched by computer，and the retrieval time was from the establishment of the database to March 17，2025. Two researchers independently searched and screened the literature，and evaluated the quality of the literature. RevMan 5.4 software was used for meta-analysis. Results A total of 8 studies involving 9 054 patients were included. The results of meta-analysis showed that，compared with the non-early mobilization group，early mobilization could reduce the mortality of ECMO patients，and the difference was statistically significant[RR=0.65，95%CI（0.46，0.93），P<0.001]. However，the effect on the duration of mechanical ventilation[SMD=-0.37，95%CI（-1.46，0.72），P=0.510] and ECMO support[SMD=-0.33，95%CI（-0.86，0.20），P=0.220] was not clear. In subgroup analysis，there was a statistically significant difference in mortality between patients with veno-venous extracorporeal membrane oxygenation（V-V ECMO） and veno-arterial extracorporeal membrane oxygenation（V-A ECMO）[RR=1.34，95%CI（1.05，1.71），P=0.020]. Conclusion The intervention of early mobilization can reduce the mortality of ECMO patients. But it is limited by the quality of the included studies，the number of subjects and the heterogeneity of study results，more high-quality studies are still needed to further verify the safety，feasibility and effectiveness of early mobilization in ECMO patients，and formulate professional progressive mobilization programs for different types of ECMO patients.

Key words: Extracorporeal Membrane Oxygenation, Early Mobilization, Nursing Care, Meta-Analysis