Abstract: To summarize the nursing experience of a patient with multiple injury complicated with multiple organ dysfunction syndrome who underwent extracorporeal membrane oxygenation combined with continuous renal replacement therapy. Conventional nursing measures were adjusted for safety problems such as pipeline fixation of extracorporeal membrane lung oxygenation,coagulation monitoring,hemodynamic disorders. Thoracic closed drainage combined with mechanical ventilation nursing and pressure injury prevention were given. According to patients' consciousness and ICU activity score,early graded rehabilitation activity program led by nurses was given,among which physical function exercise,combination of active and passive activities,and activity safety were the difficulties and key points of nursing. After 26 days of treatment and nursing,the patient's condition was improved and he was discharged. He was in good condition after 2 months of follow-up.

Key words: Multiple Organ Dysfunction Syndrome, Extracorporeal Membrane Oxygenation, Continuous Renal Replacement Therapy, Emergency Nursing